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New hope for rare eye parasite: study compares drug cocktails and steroid timing

NCT ID NCT03484507

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the best ways to treat a rare but serious eye infection called acanthamoeba keratitis, which is caused by a parasite. 49 people took part. In the first part, they received either one drug or a combination of two drugs. In the second part, they were given steroids at different times or a placebo. The goal was to see which approach cleared the infection and improved vision most effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

49 people

The number who actually took part.

Started

Jan 2018

Finished

Nov 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Trial 1 Inclusion Criteria: * Smear or culture positive for acanthamoeba * Age 13 years or greater Trial 1 Exclusion Criteria: * Interstitial or viral keratitis on history or examination * Corneal perforation * Therapeutic keratoplasty for acanthamoeba keratitis * Unwillingness or inability to follow-up (e.g., living too far from hospital) Trial 2 Inclusion Criteria * Smear or culture positive for acanthamoeba, with 4 weeks of anti-amoebic treatment * Age 13 years or greater * Willing to participate in study Trial 2 Exclusion Criteria * Interstitial or viral keratitis on history or examination * Fungus identified on culture and smear after 2 weeks of anti-amoebic treatment * Corneal perforation * Therapeutic keratoplasty for acanthamoeba keratitis * Unwillingness or inability to follow-up (e.g., living too far from hospital)

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Conditions

The condition(s) this trial relates to.

Acanthamoeba keratitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acanthamoeba keratitis

Contacts and locations

Locations

  • Aravind Eye Hospital

    Coimbatore, Tamil Nadu, India

  • Aravind Eye Hospital

    Madurai, Tamil Nadu, India

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