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New registry tracks Real-World outcomes for hypoparathyroidism treatment

NCT ID NCT01922440

Knowledge-focused Sponsor: Takeda Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study is a registry that collects information from over 1,300 people with chronic hypoparathyroidism to see how well the drug rhPTH(1-84) works and how safe it is over time in everyday medical practice. Participants receive their usual care and fill out questionnaires during routine visits. The goal is to better understand the long-term effects of this treatment on calcium levels, kidney health, and quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,339 people

The number who actually took part.

Started

Jul 2013

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This global registry is expected to enroll a minimum of 900 participants, of whom at least 300 will be participants treated with rhPTH(1-84) and at least 600 will be participants receiving standard of care. Protocol amendment 9 revised the sample size: up to 164 additional participants treated with rhPTH(1-84) (ie, up to a total of 464 participants in that cohort) will be enrolled as needed to ensure the availability of 104 rhPTH(1-84)-treated participants with a full 10 years of follow-up.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants diagnosed with chronic hypoparathyroidism, that is, hypoparathyroidism with a duration of longer than 6 months, including: 1. Adult participants (greater than or equal to \[\>=\] 18 years of age) who are receiving for chronic hypoparathyroidism any of the following options: standard therapy, standard therapy plus rhPTH(1-84), or rhPTH(1-84) therapy alone. 2. Pediatric participants (less than \[\<\] 18 years of age) who are receiving for chronic hypoparathyroidism any of the following options: standard therapy, standard therapy plus rhPTH(1-84), or rhPTH(1-84) therapy alone. Exclusion Criteria: * Participants or legally acceptable representatives unable to provide informed consent. * Participants using rhPTH(1-34) or who used rhPTH(1-34) for more than 2 years are excluded. Participants who had been treated with rhPTH(1-34) within 3 months of enrollment are also excluded as are participants currently using rhPTH(1-34). FOR US SITES ONLY: Participants treated with rhPTH(1-84) prior to the US recall may use rhPTH(1-34) only while rhPTH(1-84) is unavailable due to the recall. * Participants currently enrolled in an interventional clinical study (whether or not the study is related to hypoparathyroidism); note that this does not include participants enrolled in other observational registries. * History of hypoparathyroidism resulting from impaired responsiveness to PTH (pseudohypoparathyroidism).

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Conditions

The condition(s) this trial relates to.

hypoparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypoparathyroidism

Contacts and locations

Locations

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 54636, Greece

  • AKH Wien, Universitaetsklinik fuer Innere Medizin III

    Vienna, 1090, Austria

  • Aallborg University Hospital

    Aalborg, 9000, Denmark

  • Aarhus Universitetshospital

    Aarhus N, 8200, Denmark

  • Academy of Diabetes Thyroid and Endocrine

    El Paso, Texas, 79935, United States

  • Akademiska Sjukhuset - Uppsala University Hospital

    Uppsala, 75185, Sweden

  • Albany Med Endocrine Specialists

    Albany, New York, 12206, United States

  • Alleghany General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Azienda Ospedaliera San Giovanni Addolorata

    Roma, RM 00184, Italy

  • Azienda Ospedaliero-Universitaria Careggi

    Florence, FI 50139, Italy

  • Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza - Ospedale Molinette

    Torino, TO 10126, Italy

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Brokhin Medical PC

    Brooklyn, New York, 11223, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Charite-Universitiitsmedizin Berlin (CCM)

    Berlin, 10117, Germany

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Diabetes & Endocrine Associates, Methodist Physicians Clinic Diabetes and Endocrine Specialists

    Omaha, Nebraska, 68114, United States

  • Diabetes and Thyroid Center of Fort Worth, PLLC

    Fort Worth, Texas, 76132, United States

  • Diakonie-Klinikum Stuttgart

    Stuttgart, Baden-Wurttemberg, 70176, Germany

  • Dr. Joselito Cabaccan

    San Jose, California, 95148, United States

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Endocrine Associates of Long Island, P.C.

    Smithtown, New York, 11787, United States

  • Endocrinology Associates of Armstrong

    Indiana, Pennsylvania, 15701, United States

  • Endokrinologie Zentrum Ulm

    Ulm, 89075, Germany

  • Endokrinologikum Frankfurt

    Frankfurt, 60596, Germany

  • Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico

    Milan, MI 20122, Italy

  • General Hospital Of Athens - Korgialenio-Benakio E.E.S.

    Athens, 11526, Greece

  • General Hospital of Athens Alexandra

    Athens, 11528, Greece

  • General Hospital of Athens Georgios Gennimatas

    Athens, 11527, Greece

  • Gerald Friedman Diabetes Institute

    New York, New York, 10022, United States

  • Hallett Center for Diabetes and Endocrinology

    East Providence, Rhode Island, 02914, United States

  • Hanson Clinical Research Center

    Port Charlotte, Florida, 33952, United States

  • Harvard Medical School

    Boston, Massachusetts, 02115, United States

  • Haukeland University Hospital

    Bergen, 5012, Norway

  • Hippokrateion General Hospital of Thessaloniki

    Thessaloniki, 54642, Greece

  • Hospital Del Mar

    Barcelona, 08003, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario San Cecilio

    Granada, 18016, Spain

  • Indiana University Hospital

    Indianapolis, Indiana, 46202, United States

  • Karolinska Universitetssjukhuset Solna

    Stockholm, 17176, Sweden

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • MVZ endokrinologikum Göttingen

    Göttingen, 37075, Germany

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, 55905, United States

  • McMaster University

    Oakville, Ontario, L6J IX8, Canada

  • Mecklenburg Medical Group

    Charlotte, North Carolina, 28211, United States

  • Medicover Neu-Ulm Mvz

    Neu-Ulm, 89231, Germany

  • Medicover Neuroendokrinologie MVZ

    München, 81667, Germany

  • Medicover Oldenburg MVZ

    Oldenburg, 26122, Germany

  • Medicover Saarbuecken Mvz

    Saarbrücken, 66111, Germany

  • Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden

    Dresden, 01307, Germany

  • Medizinische Hochschule Hannover

    Hanover, Lower Saxony, 30625, Germany

  • Medizinische Universitaetsklinik Graz, Universitätsklinik Für Innere Medizin Graz

    Graz, 8036, Austria

  • Medstar Union Memorial Hospital

    Baltimore, Maryland, 21218, United States

  • Model Clinical Research

    Baltimore, Maryland, 21204, United States

  • Nordsjaellands Hospital - Hillerod

    Hilleroed, 3400, Denmark

  • Norfolk And Norwich University Hospital - Norwich Medical School

    Norwich, NR4 7UQ, United Kingdom

  • Northern Nevada Endocrinology

    Reno, Nevada, 89511, United States

  • Northshore University Health System

    Evanston, Illinois, 60201, United States

  • Nova Scotia Health Authority

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Ohio Health Research Institute

    Columbus, Ohio, 43214, United States

  • Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • Palm Research Center, Inc.

    Las Vegas, Nevada, 89128, United States

  • Physicians East, PA

    Greenville, North Carolina, 27834, United States

  • Praxis an der Kaiserreiche

    Berlin, 12159, Germany

  • Queen Elizabeth Hospital-Mindelsohn Way

    Birmingham, England, B15, United Kingdom

  • Regions Hospitalet Viborg

    Viborg, 8800, Denmark

  • Rutgers Robert Wood Johnson Medical School

    New Brunswick, New Jersey, 08901, United States

  • Rutgers-Robert Wood Johnson Medical School

    New Brunswick, New Jersey, 08901, United States

  • Spesialistsentret Pilestredet Park

    Oslo, 0176, Norway

  • State University Of New York Upstate Medical University

    Syracuse, New York, 13214, United States

  • Suburban Endocrinology & Diabetes

    Arlington Heights, Illinois, 60005, United States

  • Texas Diabetes and Endocrinology, P.A.

    Austin, Texas, 78731, United States

  • The Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 76307, United States

  • Thyroid & Endocrine Center of Florida

    Sarasota, Florida, 34239, United States

  • Thyroid Endocrinology and Diabetes

    Dallas, Texas, 75208, United States

  • Tilak Mallik, MD F.A.C.E., LCC

    Marrero, Louisiana, 70072, United States

  • Universitaet Zur Luebeck

    Lübeck, 23538, Germany

  • Universitaetsklinik Aachen

    Aachen, 52074, Germany

  • Universitaetsklinikum Wuerzburg

    Würzburg, 97080, Germany

  • Universitetssjukhuset I Linkoping

    Linköping, 58185, Sweden

  • Universitetssjukhuset I Orebro

    Örebro, 70185, Sweden

  • University Hospital Duesseldorf

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • University Physicians Group Research Division

    Staten Island, New York, 10301, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35205, United States

  • University of Arizona Medical Center

    Tucson, Arizona, 85714, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Hospitals of Leicester

    Leicester, LE1 5WW, United Kingdom

  • University of Leipzig

    Leipzig, Saxony, 04103, Germany

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

  • University of South Carolina

    Columbia, South Carolina, 29203, United States

  • University of Vermont

    South Burlington, Vermont, 05403, United States

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

  • Yale University

    New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.