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Could papaya leaves help fight dengue? new trial tests the idea

NCT ID NCT06121934

Disease control Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an extract from papaya leaves (CPLE) can help people with dengue fever. 250 adults with confirmed dengue were given either CPLE capsules or a placebo for 5 days. The main goals were to see if the extract could raise platelet counts and reduce the risk of severe disease. The trial is now complete, and results will show if this natural remedy has real benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Carica papaya leaf extract (CPLE) capsules
What this could lead to
If it works, this could offer a simple, plant-based option to help manage dengue and prevent severe complications.
What could go wrong
This is a completed phase 3 trial, but results are not yet widely confirmed. The extract may not significantly improve outcomes, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

250 people

The number who actually took part.

Started

Oct 2023

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who are confirmed dengue fever by NS1 dengue Ag or anti dengue Ab IgM positive Exclusion Criteria: * Children (\<18 years) * Currently pregnant or lactating * Patients on steroids, any immunosuppressant * Patients who received platelet transfusion during the same admission * Patient with other known causes of thrombocytopenia, including leukemia, ITP * Patients with alanine aminotransferase (ALT) levels \>150 U/L * Patient with serum creatine \>1.4 mg/dl * S. creatine kinase (CK) \>1000 U/L

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Conditions

The condition(s) this trial relates to.

dengue disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dengue

Contacts and locations

Locations

  • Bangabandhu Sheikh Mujib Medical University

    Dhaka, 1200, Bangladesh

More trials for these conditions

Other studies related to the condition(s) this trial covers.