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New study: common painkillers may be safe for new moms with severe preeclampsia

NCT ID NCT03978767

Symptom relief Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. The goal was to see if NSAIDs are a good option for managing pain without worsening high blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

287 people

The number who actually took part.

Started

Jun 2019

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women at \> 23 weeks gestational age undergoing vaginal or cesarean delivery at Barnes-Jewish Hospital with: * An antepartum diagnosis of preeclampsia with severe features * Pre-eclampsia with severe features will be defined as: * Elevated blood pressure ≥ 160/110, or * Pre-eclampsia in the setting of thrombocytopenia (platelet count \< 100,000), or * Impaired liver function (AST elevated to twice upper limit of normal), or * Persistent epigastric pain, or * Renal insufficiency (serum creatinine of 1.1 mg/dl or doubling of prior value), or * Pulmonary edema, or * New onset visual disturbance or headache unresponsive to therapy. Exclusion Criteria: * NSAID allergy * Allergy to acetaminophen * Antihypertensive use in this pregnancy prior to 20 weeks gestation * Chronic kidney disease or Acute kidney injury with Creatine clearance less than 60 mL/min * Inability to obtain consent * Opioid abuse disorder * Peptic ulcer disease.

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Conditions

The condition(s) this trial relates to.

preeclampsia severe pre-eclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Preeclampsia postpartum Preeclampsia severe

Contacts and locations

Locations

  • Barnes Jewish Hospital

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.