Could antibiotics alone replace drains for diverticulitis abscesses? new pilot study aims to find out
NCT ID NCT07352605
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This pilot study tests whether antibiotics alone are as effective as antibiotics plus percutaneous drainage for treating diverticulitis with a large abscess (4-8 cm). Fifty adults with stable vital signs and no signs of peritonitis will be randomly assigned to one of two groups. The main goal is to see if hospitals can successfully enroll and follow patients, but the study will also compare how well each treatment resolves the infection within 30 days.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Antibiotics (piperacillin-tazobactam) and/or percutaneous drainage
- What this could lead to
- If successful, this pilot could pave the way for a larger trial that clarifies whether antibiotics alone are enough for diverticulitis abscesses, potentially avoiding invasive drainage procedures.
- What could go wrong
- This is a small pilot study (50 participants) focused on feasibility, not definitive results. The findings may not apply to all patients, and there are risks of infection, bleeding, or treatment failure with either approach.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria * Patients of both sexes, ≥ 18 years old. * Patients with abdominal CT scan diagnosis of colonic AD classifiable as WSES 2A with abscess ≥4 cm and \< 8 cm in size; * Patients with haemodynamic stability at hospital admission and no clinical or radiological evidence of diffuse peritonitis. * Patients who accept and sign the informed consent Exclusion criteria * Patients with a final diagnosis other than diverticular abscess, including those diagnosed with colonic cancer. * Pregnancy or lactation. * Immunosuppressed patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
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The official record
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