New drug targets common cancer driver in first human trial
NCT ID NCT06585488
Summary
This is an early-stage study testing a new drug called BGB-53038, which is designed to block a specific protein (KRAS) that drives the growth of many advanced solid tumors. The main goal is to find a safe dose and see how the body handles the drug, both when given alone and when combined with other cancer therapies. Researchers will enroll about 514 adults with advanced cancers (like lung, colorectal, pancreatic, and stomach cancers) that have specific KRAS genetic changes.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center
RECRUITINGSongpaGu, Seoul Teugbyeolsi, 05505, South Korea
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Auckland City Hospital
RECRUITINGAuckland, 1023, New Zealand
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100142, China
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Blacktown Cancer and Haematology Centre
RECRUITINGBlacktown, New South Wales, NSW 2148, Australia
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Cancer Hospital Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100021, China
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Linear Clinical Research
RECRUITINGNedlands, Western Australia, WA 6009, Australia
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Monash Health
RECRUITINGClayton, Victoria, VIC 3168, Australia
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Peter Maccallum Cancer Centre
RECRUITINGMelbourne, Victoria, VIC 3000, Australia
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Samsung Medical Center
RECRUITINGGangnamGu, Seoul Teugbyeolsi, 06351, South Korea
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, Seoul Teugbyeolsi, 03080, South Korea
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Severance Hospital Yonsei University Health System
RECRUITINGSeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
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Shanxi Provincial Cancer Hospital
RECRUITINGTaiyuan, Shanxi, 030013, China
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Sidney Kimmel Comprehensive Cancer At Johns Hopkins
RECRUITINGBaltimore, Maryland, 21287, United States
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The University of Texas Md Anderson Cancer Center
RECRUITINGHouston, Texas, 77030-4009, United States
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University of Kansas Medical Center Research Institute
RECRUITINGKansas City, Kansas, 66160-8500, United States
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Usc Norris Comprehensive Cancer Center (Nccc)
RECRUITINGLos Angeles, California, 90089-1019, United States
Conditions
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