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New hope for Hard-to-Treat cancers: drug targets genetic weakness

NCT ID NCT04439201

First seen Mar 17, 2026 · Last updated Jun 17, 2026 · Updated 13 times

Summary

This study tests a drug called palbociclib in 40 adults with advanced cancers that have specific genetic changes (CCND1, 2, or 3 amplifications). The drug blocks certain proteins that help cancer grow. Researchers want to see if it can shrink tumors or stop them from getting worse. This is a phase II trial, meaning it's checking how well the drug works in people with these particular genetic markers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ECOG-ACRIN Cancer Research Group

    Philadelphia, Pennsylvania, 19103, United States

Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm lymphoma refractory hematologic cancer refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.