New combo aims to ease Post-Surgery pain in hysterectomy patients
NCT ID NCT07330375
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two drug combinations given through an IV to manage pain after vaginal hysterectomy. 50 women will receive either dexmedetomidine alone or with ketamine. The goal is to see which provides better pain relief and reduces the need for extra painkillers in the first 24 hours after surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who will accept written informed consent. * Age: 21-65 years old. * Sex: female. * BMI: \<35 kg/m2 * Physical status: American Society of Anesthesiology (ASA) of Grade I-II * Type of operation: vaginal hysterectomy under spinal anesthesia. Exclusion Criteria: * Uncooperative patients * Any contraindication for spinal anesthesia e.g. coagulopathy, infection at site of block, and hypersensitivity to any drug used in this study. * Patients who are known to be drug dependent.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Two nerve blocks go head to head for hip replacement pain
- Predicting pain: a new model may tailor Post-Surgery relief
- Which nerve block eases hip surgery pain better?
- Which nerve block wins for hip surgery pain?
- Which painkiller wins after hysterectomy? a Head-to-Head test