Pain relief study for smokers after lung surgery pulled before it started
NCT ID NCT07306702
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aimed to see if adding dexmedetomidine to a standard painkiller could improve pain control and comfort after lung surgery in smokers. It planned to enroll 102 men with high nicotine dependence. However, the study was withdrawn before any participants were enrolled, so no results are available.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * American Society of Anesthesiologists (ASA) physical status II-III * Male patients aged 65 years or younger * Undergoing lobectomy for the first time * High nicotine dependence, confirmed by the Fagerström Test for Nicotine Dependence (FTND) with an FTND score of 6 or higher * No history of substance abuse and no recent use of analgesic medications (e.g., opioids or non-steroidal anti-inflammatory drugs) prior to surgery * Able to understand the procedure for patient-controlled intravenous analgesia (PCIA) and able to complete the study assessment scales Exclusion Criteria * History of mental illness or cognitive disorder; or currently receiving antidepressant treatment and unable to cooperate with examinations and assessments * Bradycardia (heart rate 50 beats/min or lower) or second- or third-degree atrioventricular block * Body mass index (BMI) greater than 30 kg/m² * Use of analgesics, sedatives, beta-blockers, or alpha-2 agonists prior to surgery * Required reoperation due to serious postoperative complications (e.g., bleeding) * Severe cardiovascular, cerebrovascular, hepatic, or renal disease, resulting in inability to remove the endotracheal tube after surgery or inability to use the analgesia pump correctly * Failure to abstain from smoking for at least 2 weeks prior to surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Shenyang Chest Hospital, Department of Anesthesiology
Shenyang, Liaoning, 110044, China
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