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New study tracks silent eye changes that could lead to vision loss

NCT ID NCT07236671

Knowledge-focused Sponsor: Singapore National Eye Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 250 adults aged 45 and older who have pachychoroid, a condition where the choroid layer in the eye is abnormally thick. Researchers will track changes in the eye's veins over time to see how the condition develops and what factors might make it worse. The goal is to better understand who is at risk for vision problems and why.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors predict who is at risk for vision loss from pachychoroid and guide earlier monitoring or treatment.
What could go wrong
This is an observational study, not a treatment trial. It may not identify clear risk factors, and results may take years to emerge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will aim to recruit 170 participants in Singapore National Eye Centre (SNEC) and 50 participants in National University Hospital, 30 participants from the University of Malaya

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 45 years or older. 2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant. 3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes 4. Willing to provide written informed consent Exclusion Criteria: 1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period 2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery) 3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders 4. Pregnant or nursing women 5. Persons who are unable to give informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pachychoroid disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hong Kong University

    RECRUITING

    Hong Kong, Hong Kong

  • National University Hospital, Singapore

    RECRUITING

    Singapore, Singapore

  • Singapore National Eye Centre/ Singapore Eye Research Institute

    RECRUITING

    Singapore, Singapore

  • University of Malaya Medical Centre

    RECRUITING

    Kuala Lumpur, Malaysia

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