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Olive oil gel could replace bone grafts in dental implants

NCT ID NCT07368114

Disease control Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether ozonated olive oil gel can help dental implants fuse with the jawbone as well as a standard injectable bone graft. Sixteen adults needing a tooth replacement received an immediate implant after extraction, with either the oil gel or bone graft applied around it. Researchers measured implant stability and bone density over 6 months to compare the two approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozonated olive oil gel
What this could lead to
If it works, this could offer a simpler, less invasive alternative to bone grafts for dental implants.
What could go wrong
This is a very small Phase 2 trial with only 16 participants, so results may not apply widely. The ozonated olive oil gel may not perform as well as standard bone grafts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

16 people

The number who actually took part.

Started

Dec 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Adults aged between 20 and 60 years. * Adults of both genders. * Patients who are medically healthy and without systemic conditions that could contraindicate implant placement. * Patients requiring extraction of a single unrestorable mandibular premolar indicated for immediate implant placement. * Presence of sufficient apical and peripheral bone to achieve primary implant stability (minimum 3-5 mm of bone beyond the socket apex and overall socket length ≥ 10 mm). Exclusion criteria: * Pregnant and lactating women's * Heavy smoking (\>10 cigarettes/day) * Severe parafunctional habits (e.g., uncontrolled bruxism). * Periapical infections or lesions. * Gingival and periodontal diseases. * Inability or unwillingness to attend scheduled follow-up visits.

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Conditions

The condition(s) this trial relates to.

tooth disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone graft DENTAL Implant osseointegration Ozone therapy

Contacts and locations

Locations

  • Suez Canal University, Faculty of Dentistry

    Ismailia, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.