New blood filter may boost survival in septic shock patients on dialysis
NCT ID NCT07569406
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal was to see if the Oxiris filter was linked to better survival and kidney recovery. The study is complete, but because it is a retrospective review, it cannot prove cause and effect.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Oxiris filter (a special blood filter that removes toxins and inflammation-causing substances during dialysis)
- What this could lead to
- If the Oxiris filter is shown to improve survival and kidney recovery, it could become a standard tool for treating septic shock in intensive care.
- What could go wrong
- This is a retrospective study, not a controlled trial, so results may be influenced by other factors. The filter is already available, but its benefit over standard filters remains uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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400 people
The number who actually took part.
- Started
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Jan 2012
- Finished
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Dec 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Critically ill adult patients admitted to an intensive care unit with septic shock and acute kidney injury requiring renal replacement therapy.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients (≥18 years old) * Admission to the intensive care unit * Diagnosis of septic shock * Requirement of renal replacement therapy due to acute kidney injury * Treatment with either Oxiris filter or standard hemofilters Exclusion Criteria: * Patients under 18 years of age * Chronic dialysis prior to ICU admission * Missing key clinical data * Patients not meeting criteria for septic shock
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Clínica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
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Other studies related to the condition(s) this trial covers.
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