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New blood filter may boost survival in septic shock patients on dialysis

NCT ID NCT07569406

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal was to see if the Oxiris filter was linked to better survival and kidney recovery. The study is complete, but because it is a retrospective review, it cannot prove cause and effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oxiris filter (a special blood filter that removes toxins and inflammation-causing substances during dialysis)
What this could lead to
If the Oxiris filter is shown to improve survival and kidney recovery, it could become a standard tool for treating septic shock in intensive care.
What could go wrong
This is a retrospective study, not a controlled trial, so results may be influenced by other factors. The filter is already available, but its benefit over standard filters remains uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

400 people

The number who actually took part.

Started

Jan 2012

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Critically ill adult patients admitted to an intensive care unit with septic shock and acute kidney injury requiring renal replacement therapy.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years old) * Admission to the intensive care unit * Diagnosis of septic shock * Requirement of renal replacement therapy due to acute kidney injury * Treatment with either Oxiris filter or standard hemofilters Exclusion Criteria: * Patients under 18 years of age * Chronic dialysis prior to ICU admission * Missing key clinical data * Patients not meeting criteria for septic shock

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Clínica Universidad de Navarra

    Pamplona, Navarre, 31008, Spain

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