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Gum fluid reveals secrets of tooth movement in braces vs. aligners

NCT ID NCT07480538

Knowledge-focused Sponsor: Suleyman Demirel University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how gum fluid changes over time when teeth are moved with clear aligners or traditional braces. Researchers collected fluid samples from 32 healthy people at several time points over a month. The goal was to better understand how gum tissue responds to different types of orthodontic treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

32 people

The number who actually took part.

Started

Jun 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy individuals with no history of systemic disease * No regular pharmacological medication use within the last 6 months * Individuals with completed mixed dentition and full permanent dentition (excluding third molars) * No missing or impacted teeth other than third molars * Indication for non-extraction orthodontic treatment * Mild malocclusion with 2-4 mm crowding (Celikoglu, 2010) * Skeletal Class I relationship (0° ≤ ANB ≤ 4°) * Periodontally healthy individuals (gingival index \<1, plaque index \<1, probing depth ≤3 mm, \<10% bleeding on probing, and no radiographic bone loss) * No caries, fractures, wear, or restorations in the teeth selected for gingival crevicular fluid sampling * Absence of parafunctional habits that could cause traumatic oral lesions Exclusion Criteria: * Presence of periodontal disease or radiographic bone loss * Poor oral hygiene * Skeletal anomalies or need for orthognathic treatment * Temporomandibular joint disorders * Known allergy to any medication or material * Tobacco or alcohol use * Personal or family history of cancer or history of chemotherapy/radiotherapy * Participation in another clinical trial during the study period * Presence of mixed dentition or missing teeth other than third molars

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orthodontic tooth movement

Contacts and locations

Locations

  • Suleyman Demirel University Faculty of Dentistry Department of Periodontology

    Isparta, 32260, Turkey (Türkiye)

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