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Mouthwash showdown: can hydrogen peroxide rinse beat gum disease?

NCT ID NCT07270705

Symptom relief Sponsor: ENIKAM d.o.o. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a hydrogen peroxide mouth rinse called OROXID can help treat gingivitis, a common gum inflammation. About 90 adults with mild gum disease will use the rinse twice daily for 4 weeks, alongside regular brushing. Researchers will measure changes in gum inflammation, plaque, and bleeding to see if it works better than brushing alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hydrogen peroxide mouth rinse (OROXID)
What this could lead to
If it works, this could provide a simple, over-the-counter option to help manage gingivitis and prevent it from worsening.
What could go wrong
This is a small, early-stage trial with only 90 people. Results may not apply to everyone, and hydrogen peroxide can sometimes irritate gums or cause sensitivity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Systemically healthy participants aged 18 years or older. 2. Presence of at least 20 natural teeth. 3. Probing pocket depth less than or equal to 3 mm. 4. Presence of bleeding on probing in more than 10% of sites. 5. Mean Gingival Index (Silness \& Löe) of at least 1. 6. Ability and willingness to follow oral hygiene instructions after the intervention. 7. Signed informed consent form after being informed about the study. Exclusion Criteria: 1. Periodontal treatment within the last three months. 2. Diagnosis of periodontitis. 3. Use of mouth rinses or oral gels within the last month. 4. Use of antibiotic therapy within the last three months. 5. Known allergy or hypersensitivity to any components of the investigational products. 6. Ongoing treatment with antihypertensive, antilipemic, antiarrhythmic, or other cardiovascular medications. 7. Presence of systemic diseases such as diabetes, HIV/AIDS, liver disease, chronic kidney disease, tuberculosis, or autoimmune disorders (e.g., lupus, scleroderma, Crohn's disease). 8. Use of immunosuppressive medications. 9. Ongoing orthodontic treatment, fixed orthodontic appliance, or removable denture. 10. Pregnant or breastfeeding women. 11. Smokers.

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Conditions

The condition(s) this trial relates to.

gingivitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    2 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Klinika Križaj Ljubljana

    RECRUITING

    Ljubljana, 1000, Slovenia

  • Ustna medicina d.o.o.

    RECRUITING

    Ljubljana, 1000, Slovenia

    Contact Email: •••••@•••••

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