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A 250,000-Person study aims to sharpen heart risk prediction with CT scans

NCT ID NCT05169333

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This large observational study is collecting CT scans, blood samples, and health data from 250,000 adults to develop and validate new ways of predicting heart disease, stroke, and other cardiometabolic conditions. Participants aged 18 to 99 without active cancer are being enrolled across multiple centers. The study will follow participants for up to 15 years to see how well novel imaging and blood biomarkers predict future health outcomes, including mortality and non-fatal vascular events.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to more accurate ways to predict who is at risk for heart attacks, strokes, and other cardiometabolic diseases, enabling earlier prevention.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may take many years to emerge and may not change clinical practice immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2016

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients will be recruited from secondary and tertiary NHS care providers in the UK and from international sites.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria for study Arms 1, 2 and 3: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 -99 years. Inclusion Criteria for study Arm 4: • Male or Female, aged 18 -99 years. Exclusion Criteria: Exclusion Criteria for Study Arms 1, 2 and 3: * Unable or unwilling to consent * Active cancer Exclusion Criteria for Study Arm 4: * Participation in Study Arms 1, 2 or 3 * Existing opt-out from use of data for research purposes

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Cardiovascular risk factors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    45 sites in 14 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assistance Publique - Hôpitaux de Paris

    RECRUITING

    Paris, France

  • Barts Health NHS Trust

    RECRUITING

    London, United Kingdom

  • Bridging Medical Silos

    RECRUITING

    Tampa, Florida, United States

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, United States

  • Brooke Army Medical Center (BAMC)

    RECRUITING

    San Antonio, Texas, United States

  • Centro Cardiologico Monzino IRCCS, University of Milan

    RECRUITING

    Milan, Italy

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, United States

  • Emory University

    RECRUITING

    Atlanta, Georgia, United States

  • Friedrich-Alexander-Universitat Erlangen-Nurmberg

    RECRUITING

    Erlangen, Germany

  • Golden Jubilee National Hospital

    NOT_YET_RECRUITING

    Glasgow, United Kingdom

  • Guy's and St Thomas' NHS Foundation Trust

    RECRUITING

    London, United Kingdom

  • GØdstrup Regional hospital

    RECRUITING

    Aarhus, Denmark

  • Heart and Lung Centre, New Cross Hospital

    RECRUITING

    Wolverhampton, United Kingdom

  • Isola Tiberina-Gemelli Isola Hospital

    RECRUITING

    Roma, Italy

  • Leeds Teaching Hospitals NHS Trust

    RECRUITING

    Leeds, United Kingdom

  • Lefkos Stavros Clinic

    RECRUITING

    Athens, Greece

  • Liverpool heart and chest hospital

    NOT_YET_RECRUITING

    Liverpool, United Kingdom

  • Midwest Heart & Vascular Specialists LLC

    RECRUITING

    Kansas City, Kansas, United States

  • Milton Keynes University Hospital

    RECRUITING

    Milton Keynes, United Kingdom

  • NHS Greater Glasgow and Clyde

    NOT_YET_RECRUITING

    Glasgow, United Kingdom

  • NIH National Heart, Lunch, and Blood Institute

    RECRUITING

    Bethesda, Maryland, United States

  • National and Kapodistrian University of Athens - Hippokration Hospital

    RECRUITING

    Athens, Greece

  • Nicosia Polyclinic

    RECRUITING

    Nicosia, Cyprus

  • Oxford University Hospitals NHS Foundation Trust

    RECRUITING

    Oxford, United Kingdom

  • Royal Brompton and Harefield Hospitals

    RECRUITING

    London, United Kingdom

  • Royal Papworth Hospital NHS Trust

    RECRUITING

    Cambridge, United Kingdom

  • Royal United Hospitals Bath NHS Foundation Trust

    RECRUITING

    Bath, United Kingdom

  • Sandwell and West Birmingham Hospitals NHS Trust

    RECRUITING

    Birmingham, United Kingdom

  • Semmelweis University

    RECRUITING

    Budapest, Hungary

  • Seoul National University

    RECRUITING

    Seoul, South Korea

  • St Luke's Hospital

    RECRUITING

    Kansas City, Kansas, United States

  • Taiwan Kaohsiung Medical University

    RECRUITING

    Kaohsiung City, Taiwan

  • The Newcastle Hospitals NHS Foundation Trust

    RECRUITING

    Newcastle upon Tyne, United Kingdom

  • The University of Sydney

    NOT_YET_RECRUITING

    Sydney, Australia

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, United States

  • University Hospital Ulm

    NOT_YET_RECRUITING

    Ulm, Germany

  • University Hospital of Manchester NHS Foundation Trust

    NOT_YET_RECRUITING

    Manchester, United Kingdom

  • University Hospitals Birmingham NHS Trust

    NOT_YET_RECRUITING

    Birmingham, United Kingdom

  • University Hospitals Leuven

    NOT_YET_RECRUITING

    Leuven, Belgium

  • University Hosptials of Leicester NHS Trust

    RECRUITING

    Leicester, United Kingdom

  • University of Edinburgh, Royal Infirmary

    NOT_YET_RECRUITING

    Edinburgh, United Kingdom

  • University of Medicine and Pharmacy of Targu Mures

    RECRUITING

    Târgu Mureş, Romania

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, United States

  • Valleywise Health

    RECRUITING

    Phoenix, Arizona, United States

  • Yale University, School of Medicine

    RECRUITING

    New Haven, Connecticut, United States

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Other studies related to the condition(s) this trial covers.