New cell therapy aims to make stem cell transplants safer for blood cancer patients
NCT ID NCT05316701
First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 40 times
Summary
This study tests a new treatment called Orca-T for people with advanced blood cancers (like leukemia) who need a stem cell transplant. Orca-T uses a special mix of cells from a donor to try to prevent a serious side effect called graft-versus-host disease (GVHD) while still fighting the cancer. The study compares Orca-T to the standard transplant approach in 187 participants to see if it improves survival without severe GVHD.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Oregon Health & Sciences University - Knight Cancer Institute
Portland, Oregon, 97239, United States
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Ronald Reagan UCLA Medical Center
Los Angeles, California, 90095, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37239, United States
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Stanford Health Care
Stanford, California, 94305, United States
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UC Davis
Sacramento, California, 95817, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Miami Hospital and Clinics - Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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University of Michigan Health System - Michigan Medicine
Ann Arbor, Michigan, 48109, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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Vanderbilt University
Nashville, Tennessee, 37232, United States
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Weill Cornell Medicine - New York-Presbyterian Hospital
New York, New York, 10021, United States
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Winship Cancer Institute - Emory University
Atlanta, Georgia, 30322, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.