Orange you curious? study tests if one variety fights inflammation better
NCT ID NCT06944210
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how two types of sweet oranges—one rich in certain nutrients called carotenoids and one without—affect inflammation and oxidative stress in healthy adults. Twenty healthy people ate one of the two orange varieties daily for four weeks. Researchers measured changes in blood markers and gene activity to see if the carotenoid-rich oranges offered extra health benefits.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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May 2025
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Healthy men and women * Age Range: 25-40 years * Body mass index (BMI) with values between 21 and 29.9 kg\^m2 * Willingness to accept randomization, undergo the testing and intervention procedures, and deliver blood and stool samples * Willingness to refrain from consuming foods rich in lycopene, phytoene, and phytofluene and limit the intake of some polyphenol-rich foods * Willingness to discontinue the use of antioxidant supplements (such as carotenoid, polyphenol supplements), prebiotics and/or probiotics Exclusion Criteria: * Pregnancy/lactation * History of cardiovascular diseases, diabetes, uncontrolled hypertension, heart failure, stroke, liver, gallbladder, kidney, thyroid disease, gastrointestinal, autoimmune disorder, or cancer. * Psychiatric disease that interferes with the understanding and implementation of the intervention * History of eating disorders (such as bulimia nervosa and anorexia nervosa) in the last 5 years * Current smokers * Vegan, vegetarian, or other special diets (e.g., keto, paleo) * Use of antibiotics or laxatives in the previous month * History of substance abuse or alcohol abuse * involvement in a weight loss intervention program within the past month or weight change \> 10% * Self-report of allergic reactions to study products or their phytochemicals.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Nutrition Department, Ragle Facility, University of California Davis
Davis, California, 95616, United States
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Other studies related to the condition(s) this trial covers.
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