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Orange you curious? study tests if one variety fights inflammation better

NCT ID NCT06944210

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how two types of sweet oranges—one rich in certain nutrients called carotenoids and one without—affect inflammation and oxidative stress in healthy adults. Twenty healthy people ate one of the two orange varieties daily for four weeks. Researchers measured changes in blood markers and gene activity to see if the carotenoid-rich oranges offered extra health benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

May 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Healthy men and women * Age Range: 25-40 years * Body mass index (BMI) with values between 21 and 29.9 kg\^m2 * Willingness to accept randomization, undergo the testing and intervention procedures, and deliver blood and stool samples * Willingness to refrain from consuming foods rich in lycopene, phytoene, and phytofluene and limit the intake of some polyphenol-rich foods * Willingness to discontinue the use of antioxidant supplements (such as carotenoid, polyphenol supplements), prebiotics and/or probiotics Exclusion Criteria: * Pregnancy/lactation * History of cardiovascular diseases, diabetes, uncontrolled hypertension, heart failure, stroke, liver, gallbladder, kidney, thyroid disease, gastrointestinal, autoimmune disorder, or cancer. * Psychiatric disease that interferes with the understanding and implementation of the intervention * History of eating disorders (such as bulimia nervosa and anorexia nervosa) in the last 5 years * Current smokers * Vegan, vegetarian, or other special diets (e.g., keto, paleo) * Use of antibiotics or laxatives in the previous month * History of substance abuse or alcohol abuse * involvement in a weight loss intervention program within the past month or weight change \> 10% * Self-report of allergic reactions to study products or their phytochemicals.

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Conditions

The condition(s) this trial relates to.

Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Nutrition Department, Ragle Facility, University of California Davis

    Davis, California, 95616, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.