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Can a daily pill give you better skin?

NCT ID NCT02762032

Symptom relief Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an oral herbal supplement called PrimaVie can improve skin blood flow, hydration, elasticity, and barrier function. 45 healthy women aged 30-65 took either a low dose, high dose, or placebo pill twice daily for 14 weeks. Researchers measured skin changes using non-invasive devices.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PrimaVie herbal supplement
What this could lead to
If it works, this could point toward a natural supplement to improve skin health and appearance.
What could go wrong
This is a very early Phase 1 trial with only 45 healthy women, so results may not apply to everyone. The supplement may show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

45 people

The number who actually took part.

Started

Feb 2016

Finished

Dec 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects willing to discontinue any dietary or nutritional supplements, other than a general multivitamin, starting two weeks before onset of study and also during the study. * Subjects must be willing to maintain their present diet with no major changes throughout the study. * Subjects must be willing to take the dietary supplements as required by the study protocol twice daily. * Female subjects must be between the ages of 30 to 65 years of age * Subjects must provide written informed consent and are willing to comply with all study procedures. Exclusion Criteria: * Any dermatological disorder that may interfere with the accurate evaluation of the subject's skin. * Subjects who are pregnant, breast feeding, or planning a pregnancy. * Clinically significant unstable medical disorders. * History of, diabetes, heart or kidney disease * History of a psychological illness or condition that would interfere with their ability to understand and follow the requirements of the study. * Any skin disease in the area of the upper inner arm where the biopsies will be obtained. * Currently taking the following medications: * Steroids * Beta-blockers * Immunosuppressant's * Hydochlorothiazide, * Statins * Aspirin * ACE Inhibitors * Muscle relaxants * Stimulants * Prisoners * Males

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Davis Heart and Lung Research Institute

    Columbus, Ohio, 43210, United States

  • Martha Morehouse Medical Plaza 2050 Kenny Road

    Columbus, Ohio, 43221, United States

  • OSU Hospital East

    Columbus, Ohio, 43205, United States

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