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Mint lozenge and water additive tested for microbiome impact in 595-Person study

NCT ID NCT07451782

Knowledge-focused Sponsor: Delta Dental of Minnesota Foundation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study enrolled 595 adults aged 18 to 80 to see how two marketed oral hygiene products—a dissolvable lozenge and a water additive—affect the bacteria, fungi, and viruses living in the mouth. Participants used the products daily for 60 days, and researchers analyzed saliva and oral swabs for changes in microbes, metabolites, and inflammation markers. The goal was to understand how these non-drug products might influence oral and overall health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pHossident lozenge (dietary supplement) and Protektin water additive
What this could lead to
If successful, this could show that simple oral hygiene products can positively shift the mouth's microbiome, potentially pointing toward better ways to support oral and whole-body health without drugs.
What could go wrong
This is an early-stage observational and exploratory study, not designed to prove any health benefit. The products are supplements, not medicines, so any changes may be small or not clinically meaningful. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

595 people

The number who actually took part.

Started

Apr 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult (18 to 80 years old), all genders, all incomes, of any race (target of 20% non- Caucasian; 2. Non-smokers or those who have currently stopped for at least 2 years; 3. Can wear full dentures; 4. No oral antibiotic taken in the past 30 days; 5. May have gums that sometimes bleed upon brushing, flossing or eating; 6. Willing to take an investigational dental hygiene product, daily, for 60 days; 7. Must be able to read and understand the consent; 8. Must be willing to answer study questionnaires at the clinical site using a laptop; 9. Must be willing to participate in 3 onsite clinical visits. Exclusion Criteria: 1. Subject is pregnant or breastfeeding 2. Subject has been on an oral antibiotic within the previous 30 days; 3. Subject participated in a dental plaque/gingivitis/periodontal clinical trial within the previous 30 days; 4. If the subject reports an allergy to any of the ingredients listed in the ingredient safety information provided in the Appendix.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Basic science Biomarker discovery Intervention studies

Contacts and locations

Locations

  • Comprehensive Research Group

    Minneapolis, Minnesota, 55415, United States

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