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Saliva test may reveal hidden clues in Wilson's disease

NCT ID NCT05444127

Knowledge-focused Sponsor: Fondation Ophtalmologique Adolphe de Rothschild Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at dental health and oral quality of life in people with Wilson's disease, comparing those with liver versus neurological symptoms to healthy controls. Researchers will collect saliva samples and use questionnaires and dental exams to see if copper levels in saliva reflect treatment effectiveness. The goal is to better understand oral health problems in Wilson's disease and find new ways to monitor the condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better monitor Wilson's disease through saliva copper levels and improve dental care for patients.
What could go wrong
This is an observational study, not a treatment trial. It will not directly change how Wilson's disease is managed, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The recruitment of Wilson patients will be done in the coordinating center of the CRMR Wilson at the Fondation A de Rothschild Hospital. Control patients matched in age and sex will be identified among patients consulting in the oral medicine department of Charles Foix Hospital. Posters will be placed in the waiting room to inform patients of the existence of the study and promote recruitment.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Express consent to participate in the study * Member of or beneficiary of a social security scheme * For cases: Affected by Wilson's disease * For controls: Benefiting from a first routine dental consultation with dental panoramic imaging, outside of an emergency context or treatment follow-up/maintenance Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding women * Severe psychiatric disorders with behavioral disorders * For cases: * hepatic or neurological decompensation * liver transplant patient * For witnesses: * Patient with hepatic or neurological disease * Patient taking dietary supplements enriched with copper or zinc or zinc supplementation * Patient wearing removable prostheses with zinc-enriched prosthetic adhesives (Fixodent ProPlus®)

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Conditions

The condition(s) this trial relates to.

Wilson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Wilson disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fondation Adolphe de Rothschild

    RECRUITING

    Paris, 75019, France

  • Hopital Charles Foix

    ACTIVE_NOT_RECRUITING

    Ivry-sur-Seine, 94200, France

  • Hôpital Charles Foix

    ACTIVE_NOT_RECRUITING

    Ivry-sur-Seine, 94200, France

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