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Could a simple drink replace needles for Kids' MRI sedation?

NCT ID NCT05619627

Symptom relief Sponsor: Soroush Merchant Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This early study tests whether a liquid sedative called dexmedetomidine, given by mouth, can safely and effectively sedate children aged 3 to 6 for MRI scans. Currently, many young children need general anesthesia for MRI, which carries risks and requires needles. The trial will compare oral dexmedetomidine to standard general anesthesia in 18 children to find a safe dose that produces clear images.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine (oral sedative)
What this could lead to
If it works, this could offer a simpler, needle-free sedation option for young children needing MRI scans, reducing reliance on general anesthesia.
What could go wrong
This is a very early Phase 1 trial with only 18 participants. The drug may not provide adequate sedation for all children, and safety in this age group is still being explored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

3 to 6 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants 3-6 years old, male and female, all races and ethnicities 2. Requiring a clinically indicated MRI with general anesthesia Exclusion Criteria: 1. Refusal to take oral dexmedetomidine 2. Known allergy to dexmedetomidine 3. Inability to take dexmedetomidine at least 90 minutes prior to start of the MRI 4. Medical contraindications to administration of dexmedetomidine including: 1. Unstable cardiac status including life threatening arrhythmias, abnormal cardiac anatomy, significant cardiac dysfunction 2. Current use of digoxin 3. Moya Moya disease 4. New onset stroke 5. American Society of Anesthesiologists (ASA) physical status classification \> II 6. Contraindications to administering sedation including: 1. Active and uncontrolled gastroesophageal reflux 2. Active and uncontrolled vomiting 3. Current or recent history of apnea 4. Active respiratory disease including pneumonia, bronchitis, respiratory syncytial virus infection, asthma exacerbation 5. Craniofacial anomalies 7. Inability to have MRI scans 8. Non-English speaking volunteers

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

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