New drug duo aims to improve blood cancer treatment
NCT ID NCT05636514
First seen Jan 05, 2026 · Last updated Apr 29, 2026 · Updated 15 times
Summary
This early-phase study tests whether adding an experimental drug (defactinib) to an approved oral treatment (decitabine/cedazuridine) is safe and can work better for people with certain blood cancers like MDS, AML, and CMML. About 12 adults will take the approved drug alone for the first month, then both drugs together for five days each month. The main goal is to find the safest dose and watch for side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Concord Repatriation and General Hospital
RECRUITINGSydney, New South Wales, 2139, Australia
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Nepean Hospital
RECRUITINGSydney, New South Wales, 2747, Australia
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Prince of Wales Hospital
RECRUITINGSydney, New South Wales, 2031, Australia
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Royal Prince Alfred Hospital
RECRUITINGSydney, New South Wales, 2050, Australia
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Westmead Hospital
RECRUITINGWestmead, New South Wales, 2145, Australia
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Conditions
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