Clinical Hub For Interventional Research (choir)

This early-phase trial is testing whether combining two drugs—decitabine/cedazuridine (already approved for MDS) and the experimental drug defactinib—is safe and tolerable for people with high-risk myelodysplastic syndromes, certain acute myeloid leukemias, and chronic myelomonoc…

This study follows 100 people aged 55 and older who have clonal hematopoiesis (CH) or unexplained low blood counts. Researchers will monitor their health over time, assess risks for heart disease and blood cancers, and provide personalized support. The goal is to create a bluepri…

This study aims to develop a faster way to test new drug combinations for acute myeloid leukemia (AML). Researchers will take blood and bone marrow samples from 25 adults with AML and grow their cancer cells in special mice. They will then test how well standard treatments work i…