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Timing the trigger: could smaller follicles boost IVF success for older women?

NCT ID NCT06433518

Knowledge-focused Sponsor: Centrum Clinic IVF Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 200 women aged 35 and older with poor ovarian reserve to find the best time to trigger ovulation during IVF. One group will get the trigger when their follicles are 13-16 mm, the other when follicles are over 17 mm. Researchers will compare how many mature eggs are retrieved and how well fertilization and pregnancy rates turn out.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A group of women defined as Poseidon Group 4, who will apply to the infertility clinic to be scheduled for ovarian stimulation and assisted conception treatments during the study period.

Ages

35 to 44 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women age equal to or greater than 35 years * Women with low serum AMH (\<1,2 ng/ml), * women with low AFC (\<5) * women Undergoing assisted reproduction with Short antagonist protocol or long -agonist protocol * women who used Max daily gonadotropin dose of 300 IU Exclusion Criteria: * Age \<35 years. * Ovarian reserve parameters not meeting the POSEIDON group 4 definition. * Natural or modified natural cycles without controlled ovarian stimulation. * In vitro maturation (IVM) cycles. * Luteal-phase stimulation or DuoStim protocols. * Preimplantation genetic testing (PGT-A, PGT-M, or PGT-SR) cycles, unless prespecified for stratified analyses. * Major untreated uterine cavity pathology (e.g., submucosal fibroids, significant intrauterine adhesions, congenital uterine anomalies) or untreated hydrosalpinx. * Cycles with missing or incomplete follicular measurement data on the trigger day. * Cycles with non-standardized or undocumented trigger-to-oocyte retrieval intervals.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fertilization Fertilization in vitro

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centrum Clinic IVF Center

    RECRUITING

    Ankara, Ankara, 06800, Turkey (Türkiye)

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