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Opioid blocker may reveal Brain's social secrets

NCT ID NCT05007561

Knowledge-focused Sponsor: San Diego State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 3 times

Summary

This study tests whether blocking opioid receptors with naltrexone changes how people feel socially connected and how their brains respond to social cues. 210 healthy adults will take either naltrexone or a placebo for 7 days, report daily feelings, and undergo brain scans. The goal is to understand the role of opioids in social experiences, not to treat any condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
naltrexone
What this could lead to
If successful, this could reveal how opioids influence social bonding, potentially guiding future treatments for social disconnection.
What could go wrong
This is a very early, small study in healthy people, not a treatment trial. Results may not apply to clinical populations or lead to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

217 people

The number who actually took part.

Started

Nov 2021

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * good health * English fluency * willing to provide contact information for 4-6 close others * willing to provide digital photographs of 2 close others * own a smartphone Exclusion Criteria: * presence of medical devices, implants, or other metal objects in or on the body that cannot be removed * tattooed eyeliner * a body habitus prohibiting MRI scanning * claustrophobia * self-reported chronic mental or physical illness * current and regular use of prescription medication * previous history of having difficulty taking pills * current use of opioid analgesics * depressive symptoms above a 9 on Patient Health Questionnaire * excessive alcohol use * positive urine drug test * body mass index (BMI) greater than 35 * pregnancy or plans to become pregnant in next 6 months * positive urine pregnancy test

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Naltrexone Placebo

Contacts and locations

Locations

  • San Diego State University

    San Diego, California, 92120, United States

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