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No-Opioid anesthesia beats standard for gallbladder surgery recovery

NCT ID NCT07307625

Symptom relief Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether avoiding opioids during gallbladder surgery could improve recovery. 101 patients received either opioid-free anesthesia (using lidocaine and dexmedetomidine) or standard opioid anesthesia. The opioid-free group had less pain after surgery, needed fewer painkillers, and had less nausea and vomiting. They also woke up faster and had better early recovery scores.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine and dexmedetomidine
What this could lead to
If confirmed, this approach could offer a safer, more comfortable anesthesia option for gallbladder surgery, reducing opioid use and side effects like nausea.
What could go wrong
This was a small, single-center trial with only 101 patients. Larger, more diverse studies are needed to confirm these results and ensure safety for broader use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

101 people

The number who actually took part.

Started

Dec 2024

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 * ASA I-II * Elective laparoscopic cholecystectomy * Informed consent * BMI 18-30 kg/m² * Normal liver and renal function Exclusion Criteria: * Refusal to participate * Allergy to study drugs * Chronic opioid use * Major organ disease * Pregnancy or lactation * Open surgery conversion * Recent participation in another trial

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

General anesthesia Laparoscopic cholecystectomy Opioid-free anesthesia Postoperative nausea and vomiting Postoperative pain management

Contacts and locations

Locations

  • SBÜ Kartal Dr. Lütfi Kırdar City Hospital

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.