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Opioid study aims to personalize pain treatment for back pain sufferers

NCT ID NCT02824276

Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how oral opioids like oxycodone or morphine affect pain sensitivity in 35 adults with chronic low back pain. Participants received either the opioid or a placebo to measure changes in pain perception. The goal is to understand individual differences and improve how doctors prescribe painkillers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oxycodone or morphine sulfate immediate release (MSIR)
What this could lead to
If successful, this could help doctors tailor opioid prescriptions to individual patients for better pain relief.
What could go wrong
This is a small, early-phase study with only 35 participants, so results may not apply to everyone. Opioids also carry risks like addiction and side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

35 people

The number who actually took part.

Started

Jan 2017

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. age 25-65 2. CLBP lasting for more than 6 months as the primary complaint 3. typical pain ratings ≥ 4/10 on a visual analogue scale 4. candidate for oral opioid therapy as assessed at the BWH Pain Management Center 5. able to speak and understand English. Exclusion Criteria: 1. evidence of delirium, dementia, psychosis, or other cognitive impairment preventing completion of study procedures 2. current (i.e., active) substance use disorder (SUD) 3. past history of persistent opioid use (i.e., opioid use for more than 6 months) given that this could affect the biological systems of interest in the present study 4. history of myocardial infarction or other serious cardiovascular condition 5. current peripheral neuropathy 6. current pregnancy, or intention to become pregnant during the study 7. current intrathecal pump.

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Conditions

The condition(s) this trial relates to.

Low Back Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Low back pain

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02467, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.