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Can sugar pills without deception ease ER pain?

NCT ID NCT06408519

Symptom relief Sponsor: Bruno Minotti Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving patients open-label placebo pills (honest placebos) for acute pain in the emergency department is practical and acceptable. 57 adults with non-specific acute pain received either open-label placebo or ibuprofen. The main goal was to see if enough patients would join and follow the study, not to prove the placebo works. Results will help design larger trials on honest placebos for pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Placebo (open-label) and Ibuprofen 400 mg
What this could lead to
If successful, this could show that honest placebo pills are a feasible and acceptable option for managing acute pain in the emergency department.
What could go wrong
This is a small feasibility study (57 participants) with exploratory outcomes, so results may not be conclusive or generalizable. The placebo effect is unpredictable and may not provide adequate pain relief for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

57 people

The number who actually took part.

Started

May 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Established diagnosis of non-specific acute pain * Able to understand the study and its outcome measures * Signed informed consent * 18 years or older * Sufficient German language skills Exclusion Criteria: * Chronic pain * Treatment with pain medication for \> 7 days prior to ED visit * Known allergy or intolerance to ibuprofen * Known hereditary galactose-intolerance, lactase deficiency or glucosegalactose malabsorption * Participation in another clinical trial with medicinal products * Need for hospitalization * Known pregnancy

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Conditions

The condition(s) this trial relates to.

Acute Pain Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, acute

Contacts and locations

Locations

  • University Hospital Basel

    Basel, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.