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Fish oil not One-Size-Fits-All? gene study hints at personalized heart protection

NCT ID NCT00536185

Knowledge-focused Sponsor: USDA, Western Human Nutrition Research Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a person's genes (specifically the ALOX5 gene) affect how their body responds to fish oil supplements. Researchers gave 166 healthy African-American adults either fish oil or placebo capsules for 6 weeks. They measured markers of inflammation in the blood to see if people with certain gene variations got more heart-protective benefits from the fish oil.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fish oil (omega-3 fatty acids EPA and DHA)
What this could lead to
If successful, this could help identify who benefits most from fish oil for heart health, leading to personalized nutrition advice.
What could go wrong
This is a small, completed study looking at biological markers, not heart attacks or strokes. Results may not translate to clear health recommendations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 166 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Dec 2006

Finished

Jul 2008

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 59 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * African-American, Black, or persons of African Descent * Generally Healthy * 20 - 59 years of age Exclusion Criteria: * Chronic Diseases (Heart disease, cancer, diabetes, etc.) * Smoke \> 14 cigarettes per week * Consume \> 14 alcoholic drinks per week * Pregnant Women

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Conditions

The condition(s) this trial relates to.

heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart disease

Contacts and locations

Locations

  • Ethnich Health Institute

    Oakland, California, 94609, United States

  • UC Davis (TICON-1)

    Sacramento, California, 95820, United States

  • UC Davis, Western Human Nutrition Research Center

    Davis, California, 95616, United States

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