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Fish oil could cut morphine needs after surgery, new trial hopes

NCT ID NCT07657468

Symptom relief Sponsor: National University of La Rioja Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking omega-3 fatty acids before and after gallbladder surgery can lower the amount of morphine needed for pain. Forty adults will receive either omega-3 supplements or a placebo, plus a small dose of morphine after surgery. Researchers will measure total morphine use over 24 hours and track pain, nausea, and other side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Omega-3 fatty acids
What this could lead to
If it works, this could offer a simple, natural way to reduce morphine use after surgery, potentially lowering side effects like nausea and drowsiness.
What could go wrong
This is a small, early-phase study with only 40 participants, so results may not apply widely. Omega-3 may not significantly reduce pain or morphine needs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Able to provide written informed consent prior to any study procedures; 2. Able to communicate clearly with the Investigator and staff; 3. Males and females aged 18 to 65; 4. American Society of Anesthesiologists (ASA) risk class of I to II; 5. Patients with an indication for laparoscopic cholecystectomy. Exclusion Criteria: * Patients with reduced kidney function (serum creatinine level above 2 mg/dl). * Sensitive to local anesthetics. * A history of hepatic insufficiency. * Chronic pain. * Patients with diabetes. * Patients with Body Mass Index (BMI) greater than 35 kg/m2. * Daily intake of analgesics or corticosteroids. * Patients with Inflammatory bowel disease. * Chronic opioid use.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Pain, postoperative

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National University of La Rioja

    La Rioja, La Rioja Province, F5300ALR, Argentina

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