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New opioid aims to quiet cough during anesthesia

NCT ID NCT07660380

Symptom relief Sponsor: Shiyou Wei Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This trial tests whether oliceridine, a newer opioid, causes less coughing than the standard drug sufentanil when given at the start of general anesthesia. Coughing during this phase can be dangerous, especially for patients with high pressure in the head or eyes. The study involves adults scheduled for elective surgery and will measure cough frequency, severity, and safety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oliceridine
What this could lead to
If oliceridine causes less coughing than sufentanil during anesthesia induction, it could become a safer option for patients, especially those at risk of complications from coughing.
What could go wrong
This is a small, single-center trial, so results may not apply to all patients. Oliceridine may not reduce cough as hoped, or could have other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 to 99 years. * American Society of Anesthesiologists (ASA) physical status classification I, II, or III. * Body mass index (BMI) between 18.5 and 28.0 kg/m². * Scheduled for elective surgery under general anaesthesia. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Preoperative upper respiratory tract infection symptoms (e.g., cough, expectoration, or fever) or a history of bronchial asthma or other conditions associated with increased airway reactivity. * Severe cardiovascular disease (e.g., uncontrolled hypertension, recent myocardial infarction, or serious arrhythmia) or hepatic or renal dysfunction. * Long-term opioid use, defined as continuous opioid use for more than 2 weeks within the 3 months prior to surgery. * Known hypersensitivity to any study drug or anaesthetic agent used in this protocol. * Anticipated difficult airway requiring awake intubation. * Pregnancy or breastfeeding.

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Conditions

The condition(s) this trial relates to.

Cough

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Cough

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tianmen First People's Hospital

    RECRUITING

    Tianmen, Hubei, 431700, China

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