New study pinpoints oliceridine dose to keep blood pressure steady during intubation
NCT ID NCT07154979
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested different doses of oliceridine, a painkiller, to find the amount that best prevents sudden rises in blood pressure and heart rate when a breathing tube is placed during anesthesia. Researchers enrolled 58 adults having elective surgery and adjusted doses based on age. The goal was to identify the effective dose for safer anesthesia induction.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oliceridine (TRV130)
- What this could lead to
- If successful, this could help doctors choose the safest dose of oliceridine to prevent dangerous blood pressure spikes during anesthesia, especially for older patients.
- What could go wrong
- This is a small, completed dose-finding study, not a large trial testing long-term outcomes. The results may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
58 people
The number who actually took part.
- Started
-
Sep 2025
- Finished
-
Sep 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 99 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Elective surgery requiring general anesthesia with tracheal intubation * Age ≥ 18 years * American Society of Anesthesiologists (ASA) physical status I-III * BMI\<25 Exclusion Criteria: * At rest in the operating room, systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 110 mmHg or heart rate ≥ 110 bpm * Preoperative long-term use of analgesic or sedative medications * Pregnancy, breastfeeding, known or planned pregnancy * Known allergy or hypersensitivity to oliceridine or any study medication components * History of psychiatric illness or inability to communicate effectively
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tianmen First People's Hospital
Tianmen, Hubei, 431700, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.