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New pain drug may cut Post-Surgery nausea

NCT ID NCT06411665

Symptom relief Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oliceridine
What this could lead to
If it works, this could offer a pain relief option with fewer side effects like nausea and vomiting after surgery.
What could go wrong
This is a small, completed Phase 4 trial. Results may not apply to other surgeries or patients, and oliceridine may still cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

252 people

The number who actually took part.

Started

Jul 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged between 18 and 80 years; 2. Scheduled to undergo elective laparoscopic colorectal surgery; 3. Required patient-controlled intravenous analgesia. Exclusion Criteria: 1. Pregnancy. 2. Severe heart dysfunction (New York Heart Association functional classification 4), hepatic insufficiency (Child-Pugh grade C), renal insufficiency (serum creatinine of 442 μmol/L or above, or requirement of renal replacement therapy), or Amercian Society of Anesthesiologists classification IV or above. 3. Unable to complete preoperative assessment due to severe dementia or language barrier. 4. Other conditions that are considered unsuitable for study participation.

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Conditions

The condition(s) this trial relates to.

anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laparoscopic colorectal surgery Morphine Oliceridine Postoperative analgesia Postoperative nausea and vomiting

Contacts and locations

Locations

  • Dong-Xin Wang

    Beijing, 100034, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.