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New drug combo may outperform chemo for returning ovarian cancer

NCT ID NCT02446600

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests whether olaparib (a targeted drug) alone or combined with cediranib (which blocks tumor blood vessels) works better than standard platinum chemo for women whose ovarian, fallopian tube, or peritoneal cancer has returned after initial treatment. About 579 participants with platinum-sensitive cancer are enrolled. The main goal is to see how long the cancer stays under control before growing again.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

579 people

The number who actually took part.

Started

Mar 2016

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must have platinum-sensitive recurrent high-grade serous or high-grade endometrioid ovarian, primary peritoneal, or fallopian tube cancers; patients with other (clear cell, mixed epithelial, undifferentiated carcinoma, or transitional cell carcinoma) high-risk histologies are also eligible, provided that the patient has a known deleterious germline BRCA1 or BRCA2 mutation identified through testing at a clinical laboratory; Note: Due to the long acceptance of germline BRCA testing through Myriad, Myriad testing will be accepted; if testing for germline BRCA is done by other organizations, documentation from a qualified medical professional (e.g., ovarian cancer specialty physician involved in the field, high risk genetics physician, genetics counselor) listing the mutation and confirming that the laboratory results showed a recognized germline deleterious BRCA1 or BRCA2 mutation or BRCA rearrangement is required; please collect a copy of Myriad or other BRCA mutational analysis (positive or VUS or negative) reports * Platinum-sensitive disease defined as no clinical or radiographic evidence of disease recurrence for \> 6 months (or 182 days) after last receipt of platinum-based therapy * Patients must have had a complete clinical response to their prior line of platinum therapy and cannot have had progression through prior platinum-based therapy * Patients must have signed an approved informed consent and authorization permitting release of personal health information * Patients must have evaluable disease - defined as one of the following: * Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 measurable disease OR * Evaluable disease (defined as solid and/or cystic abnormalities on radiographic imaging that do not meet RECIST 1.1 definitions for target lesions OR ascites and/or pleural effusion that has been pathologically demonstrated to be disease-related) AND a cancer antigen 125 (CA125) that has doubled from the post-treatment nadir and is also greater than 2 times upper limit of normal (ULN) * Prior therapy: * Prior chemotherapy must have included a first-line platinum-based regimen with or without intravenous consolidation chemotherapy * Patients may have received an unlimited number of platinum-based therapies in the recurrent setting * Patients may have received up to 1 non-platinum-based line of therapy in the recurrent setting; prior hormonal therapy will not be considered to count as this non-platinum-based line * Patients may not have had a prior anti-angiogenic agent in the recurrent setting; prior use of bevacizumab in the upfront or upfront maintenance setting is allowed * Patients may not have previously received a poly adenosine diphosphate (ADP) ribose polymerase (PARP)-inhibitor * Prior hormonal-based therapy for ovarian, primary peritoneal, or fallopian tube cancer is acceptable * Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2 (Karnofsky \>= 60%) * Absolute neutrophil count \>= 1,500/mcL * Platelets \>= 100,000/mcL * Hemoglobin \>= 10 g/dL * Creatinine =\< the institutional upper limit of normal (ULN) OR creatinine clearance \>= 60 mL/min/1.73 m\^2 for patients with creatinine levels above institutional normal * Urine protein: creatinine ratio (UPC) of =\< 1 or less than or equal to 2+ proteinuria on two consecutive dipsticks taken no less than 1 week apart; UPC is the preferred test; patients with \>= 2+ proteinuria on dipstick must also have a 24 hour urine collection demonstrating =\< 500 mg over 24 hours * Total bilirubin =\< 1.5 x the institutional ULN * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 3 times institutional ULN * Toxicities of prior therapy (excepting alopecia) should be resolved to less than or equal to grade 1 as per National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE); patients with long-standing stable grade 2 neuropathy may be considered after discussion with the overall principal investigator (PI), but may not receive carboplatin and paclitaxel as the reference regimen, if randomized to that arm * Patients must be able to swallow and retain oral medications and without gastrointestinal illnesses that would preclude absorption of cediranib or olaparib * Patients must have adequately controlled blood pressure (BP), with a BP no greater than 140 mmHg (systolic) and 90 mmHg (diastolic) for eligibility; patients must have a BP of =\< 140/90 mmHg taken in the clinic setting by a medical professional within 2 weeks prior to starting study; patients with hypertension may be managed with up to a maximum of three antihypertensive medications; it is strongly recommended that patients who are on three antihypertensive medications be followed by a cardiologist or blood pressure specialist for management of blood pressure while on protocol * Patients must be willing and able to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients randomized to Arm III * Cediranib has been shown to terminate fetal development in the rat, as expected for a process dependent on VEGF signaling; for this reason, women of child-bearing potential must have a negative pregnancy test prior to study entry; women of child-bearing potential must agree to use two reliable forms of contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 weeks after cediranib discontinuation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately * Adequately controlled thyroid function, with no symptoms of thyroid dysfunction and thyroid stimulating hormone (TSH) within normal limits * Age \>= 18 Exclusion Criteria: * Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) of starting treatment or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier; patients may not have had hormonal therapy within 2 weeks prior to entering the study; patients receiving raloxifene for bone health as per Food and Drug Administration (FDA) indication may remain on raloxifene absent other drug interactions * Patients may not be receiving any other investigational agents nor have participated in an investigational trial within the past 4 weeks * Patients may not be receiving any medication that may markedly affect renal function (e.g., vancomycin, amphotericin, pentamidine) * Patients may not have received prior treatment affecting the vascular endothelial growth factor (VEGF) pathway (including, but not limited to thalidomide, sunitinib, pazopanib, sorafenib, and nintedanib); bevacizumab used in the upfront setting in conjunction with chemotherapy and/or as maintenance to treat newly diagnosed disease will be allowed * Patients may not have previously received a PARP inhibitor * CA-125 only disease without RECIST 1.1 measurable or otherwise evaluable disease * Patients with untreated brain metastases, spinal cord compression, or evidence of symptomatic brain metastases or leptomeningeal disease as noted on CT or MRI scans should not be included on this study, since neurologic dysfunction may confound the evaluation of neurologic and other adverse events; screening imaging to rule out brain metastases is not required for screening, but should be performed prior to study enrollment if clinically indicated; patients with treated brain metastases and resolution of any associated symptoms must demonstrate stable post-therapeutic imaging for at least 6 months following therapy prior to starting study drug * History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib * Participants receiving any medications or substances that are strong inhibitors or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) are ineligible; strong inhibitors and inducers of UGT/PgP should be used with caution * History of gastrointestinal perforation; patients with a history of abdominal fistula will be considered eligible if the fistula was surgically repaired or has healed, there has been no evidence of fistula for at least 6 months, and patient is deemed to be at low risk of recurrent fistula * History of intra-abdominal abscess within the past 3 months * Current signs and/or symptoms of bowel obstruction or signs and/or symptoms of bowel obstruction within 3 months prior to starting study drugs * Dependency on intravenous (IV) hydration or total parenteral nutrition (TPN) * Any concomitant or prior invasive malignancies with the following curatively treated exceptions: * Treated limited stage basal cell or squamous cell carcinoma of the skin * Carcinoma in situ of the breast or cervix * Primary endometrial cancer meeting the following conditions: stage not greater than IA, grade 1 or 2, no more than superficial myometrial invasion, without vascular or lymphatic invasion; no poorly differentiated subtypes, including papillary serous/serous, clear cell, or other International Federation of Gynecology and Obstetrics (FIGO) grade 3 lesions * Prior cancer treated with a curative intent with no evidence of recurrent disease 3 years following diagnosis and judged by the investigator to be at low risk of recurrence * Patients with any of the following: * History of myocardial infarction within six months * Unstable angina * Resting electrocardiogram (ECG) with clinically significant abnormal findings * New York Heart Association (NYHA) classification of III or IV * If cardiac function assessment is clinically indicated or performed: left ventricular ejection fraction (LVEF) less than normal per institutional guidelines, or \< 55%, if threshold for normal not otherwise specified by institutional guidelines * Patients with the following risk factors should have a baseline cardiac function assessment: * Prior treatment with anthracyclines * Prior treatment with trastuzumab * Prior central thoracic radiation therapy (RT), including RT to the heart * History of myocardial infarction within 6 to 12 months (patients with history of myocardial infarction within 6 months are excluded from the study) * Prior history of impaired cardiac function * History of stroke or transient ischemic attack within six months * Any prior history of hypertensive crisis or hypertensive encephalopathy * Clinically significant peripheral vascular disease or vascular disease (including aortic aneurysm or aortic dissection) * Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to starting cediranib * Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia (other than atrial fibrillation with controlled ventricular rate), or psychiatric illness/social situations that would limit compliance with study requirements * Pregnant women are excluded from this study because cediranib and olaparib are agents with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk of adverse events in nursing infants secondary to treatment of the mother with cediranib and olaparib, breastfeeding should be discontinued if the mother is treated with cediranib or olaparib; these potential risks may also apply to other agents used in this study * Known HIV-positive individuals are ineligible because of the potential for pharmacokinetic interactions with cediranib or olaparib; in addition, these individuals are at increased risk of lethal infections when treated with marrow-suppressive therapy * Patients may not use any complementary or alternative medicines including natural herbal products or folk remedies as they may interfere with the effectiveness of the study treatments * No features suggestive of myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) on peripheral blood smear or bone marrow biopsy, if clinically indicated * No prior allogeneic bone marrow transplant or double umbilical cord blood transplantation (dUBCT)

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Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma fallopian tube clear cell adenocarcinoma fallopian tube neoplasm fallopian tube transitional cell carcinoma ovarian cancer ovarian carcinoma ovarian clear cell adenocarcinoma ovarian endometrial cancer ovarian endometrioid adenocarcinoma ovarian seromucinous carcinoma ovarian serous tumor ovarian transitional cell carcinoma primary peritoneal carcinoma undifferentiated ovarian carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fallopian tube clear cell adenocarcinoma Fallopian tube transitional cell carcinoma Fallopian tube undifferentiated carcinoma Ovarian clear cell adenocarcinoma Ovarian endometrioid tumor Ovarian seromucinous carcinoma Ovarian serous tumor Ovarian transitional cell carcinoma Ovarian undifferentiated carcinoma Recurrent fallopian tube carcinoma Recurrent ovarian carcinoma Recurrent ovarian endometrioid adenocarcinoma Recurrent primary peritoneal carcinoma

Contacts and locations

Locations

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota, 55407, United States

  • Adams Cancer Center

    Gettysburg, Pennsylvania, 17325, United States

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508, United States

  • Alegent Health Bergan Mercy Medical Center

    Omaha, Nebraska, 68124, United States

  • Alegent Health Lakeside Hospital

    Omaha, Nebraska, 68130, United States

  • Algoma District Cancer Program Sault Area Hospital

    Sault Ste. Marie, Ontario, P6B 0A8, Canada

  • AnMed Health Cancer Center

    Anderson, South Carolina, 29621, United States

  • Arizona Oncology Associates-West Orange Grove

    Tucson, Arizona, 85704, United States

  • Arizona Oncology Associates-Wilmot

    Tucson, Arizona, 85710, United States

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Ascension Saint Vincent Indianapolis Hospital

    Indianapolis, Indiana, 46260, United States

  • Ascension Via Christi Hospitals Wichita

    Wichita, Kansas, 67214, United States

  • Aspirus Cancer Care - Stevens Point

    Stevens Point, Wisconsin, 54481, United States

  • Associates In Womens Health

    Wichita, Kansas, 67208, United States

  • Atrium Health Navicent

    Macon, Georgia, 31201, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • Ballad Health Cancer Care - Kingsport

    Kingsport, Tennessee, 37660, United States

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110, United States

  • Beebe Health Campus

    Rehoboth Beach, Delaware, 19971, United States

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Billings Clinic Cancer Center

    Billings, Montana, 59101, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847, United States

  • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

    Québec, Quebec, G1R 2J6, Canada

  • CHUM - Centre Hospitalier de l'Universite de Montreal

    Montreal, Quebec, H2X 3E4, Canada

  • CIUSSSEMTL-Hopital Maisonneuve-Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • California Pacific Medical Center-Pacific Campus

    San Francisco, California, 94115, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware, 19718, United States

  • Cleveland Clinic Akron General

    Akron, Ohio, 44307, United States

  • Cleveland Clinic Cancer Center/Fairview Hospital

    Cleveland, Ohio, 44111, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Columbus Oncology and Hematology Associates Inc

    Columbus, Ohio, 43214, United States

  • Community Medical Center

    Missoula, Montana, 59804, United States

  • Cooper Hospital University Medical Center

    Camden, New Jersey, 08103, United States

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan, 49503, United States

  • Cotton O'Neil Cancer Center / Stormont Vail Health

    Topeka, Kansas, 66606, United States

  • Covenant Health Cancer Centers

    Knoxville, Tennessee, 37916, United States

  • Covenant Health Cancer Centers - West

    Knoxville, Tennessee, 37932, United States

  • CoxHealth South Hospital

    Springfield, Missouri, 65807, United States

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dartmouth Cancer Center - Nashua

    Nashua, New Hampshire, 03063, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Dickstein Cancer Treatment Center

    White Plains, New York, 10601, United States

  • Duke Cancer Center Raleigh

    Raleigh, North Carolina, 27609, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Eastern Maine Medical Center

    Bangor, Maine, 04401, United States

  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia, 25701, United States

  • Emory Decatur Hospital

    Decatur, Georgia, 30033, United States

  • Englewood Hospital and Medical Center

    Englewood, New Jersey, 07631, United States

  • Ephrata Cancer Center

    Ephrata, Pennsylvania, 17522, United States

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota, 55369, United States

  • Fairview Ridges Hospital

    Burnsville, Minnesota, 55337, United States

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435, United States

  • FirstHealth of the Carolinas-Moore Regional Hospital

    Pinehurst, North Carolina, 28374, United States

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822, United States

  • Geisinger Medical Oncology-Selinsgrove

    Selinsgrove, Pennsylvania, 17870, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • Gibbs Cancer Center-Gaffney

    Gaffney, South Carolina, 29341, United States

  • Gibbs Cancer Center-Pelham

    Greer, South Carolina, 29651, United States

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220, United States

  • Grandview Hospital

    Dayton, Ohio, 45405, United States

  • Greater Baltimore Medical Center

    Baltimore, Maryland, 21204, United States

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin, 54601, United States

  • Guthrie Medical Group PC-Robert Packer Hospital

    Sayre, Pennsylvania, 18840, United States

  • Hartford Hospital

    Hartford, Connecticut, 06102, United States

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713, United States

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan, 48183, United States

  • Henry Ford Health Providence Southfield Hospital

    Southfield, Michigan, 48075, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan, 48038, United States

  • Henry Ford West Bloomfield Hospital

    West Bloomfield, Michigan, 48322, United States

  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio, 44124, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Houston Methodist Sugar Land Hospital

    Sugar Land, Texas, 77479, United States

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Intermountain Health Lutheran Hospital

    Wheat Ridge, Colorado, 80401, United States

  • Intermountain Medical Center

    Murray, Utah, 84107, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Iwate Medical University Hospital

    Shiwa-gun, Iwate, 028-3695, Japan

  • Jefferson Abington Hospital

    Abington, Pennsylvania, 19001, United States

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • John H Stroger Jr Hospital of Cook County

    Chicago, Illinois, 60612, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, L8V 5C2, Canada

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington, 99336, United States

  • Kagoshima City Hospital

    Kagoshima, Kagoshima-ken, 890-8760, Japan

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California, 95051, United States

  • Kaiser Permanente Northwest

    Portland, Oregon, 97227, United States

  • Kaiser Permanente Sacramento Medical Center

    Sacramento, California, 95825, United States

  • Kaiser Permanente-Franklin

    Denver, Colorado, 80205, United States

  • Kaiser Permanente-Lone Tree

    Lone Tree, Colorado, 80124, United States

  • Kaiser Permanente-Oakland

    Oakland, California, 94611, United States

  • Kaiser Permanente-Rock Creek

    Lafayette, Colorado, 80026, United States

  • Kaiser Permanente-San Francisco

    San Francisco, California, 94115, United States

  • Kaiser Permanente-Vallejo

    Vallejo, California, 94589, United States

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California, 94596, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine, 04412, United States

  • Lahey Clinic

    Burlington, Massachusetts, 01805, United States

  • Lancaster General Hospital

    Lancaster, Pennsylvania, 17602, United States

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York, 10016, United States

  • Legacy Good Samaritan Hospital and Medical Center

    Portland, Oregon, 97210, United States

  • Legacy Meridian Park Hospital

    Tualatin, Oregon, 97062, United States

  • Legacy Mount Hood Medical Center

    Gresham, Oregon, 97030, United States

  • Legacy Salmon Creek Hospital

    Vancouver, Washington, 98686, United States

  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

    Savannah, Georgia, 31405, United States

  • Logan Health Medical Center

    Kalispell, Montana, 59901, United States

  • London Regional Cancer Program

    London, Ontario, N6A 4L6, Canada

  • MD Anderson Cancer Center at Cooper-Voorhees

    Voorhees Township, New Jersey, 08043, United States

  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine, 04074, United States

  • Marin Cancer Care Inc

    Greenbrae, California, 94904, United States

  • Marshfield Clinic - Wisconsin Rapids Center

    Wisconsin Rapids, Wisconsin, 54494, United States

  • Marshfield Clinic Cancer Center at Sacred Heart

    Eau Claire, Wisconsin, 54701, United States

  • Marshfield Clinic-Chippewa Center

    Chippewa Falls, Wisconsin, 54729, United States

  • Marshfield Clinic-Wausau Center

    Wausau, Wisconsin, 54401, United States

  • Marshfield Medical Center - Ladysmith

    Ladysmith, Wisconsin, 54848, United States

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Medical Center - Weston

    Weston, Wisconsin, 54476, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868, United States

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482, United States

  • Mary Bird Perkins Cancer Center

    Baton Rouge, Louisiana, 70809, United States

  • Mayo Clinic Health Systems-Mankato

    Mankato, Minnesota, 56001, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute

    Baltimore, Maryland, 21237, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Health University Medical Center

    Savannah, Georgia, 31404, United States

  • Memorial Medical Center-Las Cruces

    Las Cruces, New Mexico, 88011, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Mercy Cancer Center - Sacramento

    Sacramento, California, 95816, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433, United States

  • Mercy Hospital Joplin

    Joplin, Missouri, 64804, United States

  • Mercy Hospital Pittsburg

    Pittsburg, Kansas, 66762, United States

  • Mercy Hospital Springfield

    Springfield, Missouri, 65804, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Mercy San Juan Medical Center

    Carmichael, California, 95608, United States

  • Methodist Willowbrook Hospital

    Houston, Texas, 77070, United States

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109, United States

  • Middlesex Hospital

    Middletown, Connecticut, 06457, United States

  • Minnesota Oncology Hematology PA-Woodbury

    Woodbury, Minnesota, 55125, United States

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York, 10461, United States

  • Munson Medical Center

    Traverse City, Michigan, 49684, United States

  • National Cancer Center Hospital

    Tokyo, 104 0045, Japan

  • Nebraska Cancer Specialists/Oncology Hematology West PC

    Grand Island, Nebraska, 68803, United States

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114, United States

  • NorthShore University HealthSystem-Evanston Hospital

    Evanston, Illinois, 60201, United States

  • NorthShore University HealthSystem-Glenbrook Hospital

    Glenview, Illinois, 60026, United States

  • NorthShore University HealthSystem-Highland Park Hospital

    Highland Park, Illinois, 60035, United States

  • Northside Hospital

    Atlanta, Georgia, 30342, United States

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois, 60134, United States

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois, 60555, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Norton Brownsboro Hospital and Medical Campus

    Louisville, Kentucky, 40241, United States

  • Norton Hospital Pavilion and Medical Campus

    Louisville, Kentucky, 40202, United States

  • Norton Suburban Hospital and Medical Campus

    Louisville, Kentucky, 40207, United States

  • Novant Health New Hanover Regional Medical Center

    Wilmington, North Carolina, 28401, United States

  • OSF Saint Francis Hospital and Medical Group

    Escanaba, Michigan, 49829, United States

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana, 70121, United States

  • Odette Cancer Centre- Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Oklahoma Cancer Specialists and Research Institute-Tulsa

    Tulsa, Oklahoma, 74146, United States

  • Orion Cancer Care

    Findlay, Ohio, 45840, United States

  • Ottawa Hospital and Cancer Center-General Campus

    Ottawa, Ontario, K1H 8L6, Canada

  • PCR Oncology

    Arroyo Grande, California, 93420, United States

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401, United States

  • Pacific Gynecology Specialists

    Seattle, Washington, 98104, United States

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California, 94301, United States

  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California, 94040, United States

  • Palo Alto Medical Foundation-Gynecologic Oncology

    Mountain View, California, 94040, United States

  • Palo Alto Medical Foundation-Santa Cruz

    Santa Cruz, California, 95065, United States

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California, 94086, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416, United States

  • Parkland Memorial Hospital

    Dallas, Texas, 75235, United States

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907, United States

  • Piedmont Hospital

    Atlanta, Georgia, 30309, United States

  • Poudre Valley Hospital

    Fort Collins, Colorado, 80524, United States

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605, United States

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin, 53149, United States

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin, 53066, United States

  • ProHealth Waukesha Memorial Hospital

    Waukesha, Wisconsin, 53188, United States

  • ProMedica Flower Hospital

    Sylvania, Ohio, 43560, United States

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio, 43606, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Rapid City Regional Hospital

    Rapid City, South Dakota, 57701, United States

  • Reading Hospital

    West Reading, Pennsylvania, 19611, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Riverside Methodist Hospital

    Columbus, Ohio, 43214, United States

  • Rocky Mountain Cancer Centers-Aurora

    Aurora, Colorado, 80012, United States

  • Rocky Mountain Cancer Centers-Littleton

    Littleton, Colorado, 80120, United States

  • Rocky Mountain Cancer Centers-Rose

    Denver, Colorado, 80220, United States

  • Rocky Mountain Cancer Centers-Sky Ridge

    Lone Tree, Colorado, 80124, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Rush MD Anderson Cancer Center

    Chicago, Illinois, 60612, United States

  • Rush-Copley Medical Center

    Aurora, Illinois, 60504, United States

  • SMC Center for Hematology Oncology Union

    Union, South Carolina, 29379, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706, United States

  • Saint Charles Health System

    Bend, Oregon, 97701, United States

  • Saint Dominic-Jackson Memorial Hospital

    Jackson, Mississippi, 39216, United States

  • Saint Francis Cancer Center

    Greenville, South Carolina, 29607, United States

  • Saint Francis Hospital

    Greenville, South Carolina, 29601, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint Francis Regional Medical Center

    Shakopee, Minnesota, 55379, United States

  • Saint George Regional Medical Center

    St. George, Utah, 84770, United States

  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota, 55109, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83687, United States

  • Saint Luke's University Hospital-Bethlehem Campus

    Bethlehem, Pennsylvania, 18015, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Marinette

    Marinette, Wisconsin, 54143, United States

  • Saint Vincent Hospital Cancer Center at Oconto Falls

    Oconto Falls, Wisconsin, 54154, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    Green Bay, Wisconsin, 54303, United States

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    Sturgeon Bay, Wisconsin, 54235-1495, United States

  • Saitama Medical University International Medical Center

    Saitama, 350-1298, Japan

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Schoolcraft Memorial Hospital

    Manistique, Michigan, 49854, United States

  • Seoul National University Hospital

    Seoul, 110-744, South Korea

  • Sibley Memorial Hospital

    Washington D.C., District of Columbia, 20016, United States

  • Skagit Regional Health Cancer Care Center

    Mount Vernon, Washington, 98274, United States

  • Skagit Valley Hospital

    Mount Vernon, Washington, 98274, United States

  • Smilow Cancer Hospital Care Center at Saint Francis

    Hartford, Connecticut, 06105, United States

  • Smilow Cancer Hospital Care Center-Fairfield

    Fairfield, Connecticut, 06824, United States

  • Smilow Cancer Hospital Care Center-Trumbull

    Trumbull, Connecticut, 06611, United States

  • Smilow Cancer Hospital-Torrington Care Center

    Torrington, Connecticut, 06790, United States

  • South Carolina Cancer Specialists PC

    Hilton Head Island, South Carolina, 29926-3827, United States

  • Southeastern Medical Oncology Center-Goldsboro

    Goldsboro, North Carolina, 27534, United States

  • Southeastern Medical Oncology Center-Jacksonville

    Jacksonville, North Carolina, 28546, United States

  • Southwest Gynecologic Oncology Associates Inc

    Albuquerque, New Mexico, 87106, United States

  • Spartanburg Medical Center

    Spartanburg, South Carolina, 29303, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    Springfield, Illinois, 62781, United States

  • State University of New York Downstate Medical Center

    Brooklyn, New York, 11203, United States

  • Sudarshan K Sharma MD Limited-Gynecologic Oncology

    Hinsdale, Illinois, 60521, United States

  • Summa Health System - Akron Campus

    Akron, Ohio, 44304, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sutter Pacific Medical Foundation

    Santa Rosa, California, 95403, United States

  • Sutter Roseville Medical Center

    Roseville, California, 95661, United States

  • Swedish Medical Center-First Hill

    Seattle, Washington, 98122, United States

  • Texas Oncology - Central Austin Cancer Center

    Austin, Texas, 78731, United States

  • Texas Oncology - Fort Worth Cancer Center

    Fort Worth, Texas, 76104, United States

  • Texas Oncology - South Austin Cancer Center

    Austin, Texas, 78745, United States

  • Texas Oncology Bedford

    Bedford, Texas, 76022, United States

  • Texas Oncology-The Woodlands

    The Woodlands, Texas, 77380, United States

  • The Cancer Institute Hospital Of JFCR

    Koto-ku, Tokyo, 135-8550, Japan

  • The Hospital of Central Connecticut

    New Britain, Connecticut, 06050, United States

  • The Mark H Zangmeister Center

    Columbus, Ohio, 43219, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • TidalHealth Nanticoke / Allen Cancer Center

    Seaford, Delaware, 19973, United States

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247, United States

  • Trinity Cancer Care Center

    Minot, North Dakota, 58701, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan, 48341, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado, 80909, United States

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • UCSF Medical Center-Mission Bay

    San Francisco, California, 94158, United States

  • UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital

    Chicago, Illinois, 60657, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio, 44060, United States

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio, 44122, United States

  • UHHS-Westlake Medical Center

    Westlake, Ohio, 44145, United States

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa, 50309, United States

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314, United States

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • UPMC Susquehanna

    Williamsport, Pennsylvania, 17701, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin, 53188, United States

  • United Hospital

    Saint Paul, Minnesota, 55102, United States

  • University Cancer and Blood Center LLC

    Athens, Georgia, 30607, United States

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University Hospitals Sharon Health Center

    Wadsworth, Ohio, 44281, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland Shore Medical Center at Easton

    Easton, Maryland, 21601, United States

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan, 48912, United States

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pennsylvania/Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of South Alabama Mitchell Cancer Institute

    Mobile, Alabama, 36688, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • University of Washington Medical Center - Northwest

    Seattle, Washington, 98133, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • Utah Cancer Specialists-Salt Lake City

    Salt Lake City, Utah, 84106, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Weisberg Cancer Treatment Center

    Farmington Hills, Michigan, 48334, United States

  • WellSpan Health-York Hospital

    York, Pennsylvania, 17403, United States

  • Wellmont Holston Valley Hospital and Medical Center

    Kingsport, Tennessee, 37660, United States

  • Wellmont Medical Associates Oncology and Hematology-Johnson City

    Johnson City, Tennessee, 37604, United States

  • Wenatchee Valley Hospital and Clinics

    Wenatchee, Washington, 98801, United States

  • Wentworth-Douglass Hospital

    Dover, New Hampshire, 03820, United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007, United States

  • West Penn Hospital

    Pittsburgh, Pennsylvania, 15224, United States

  • West Virginia University Charleston Division

    Charleston, West Virginia, 25304, United States

  • Willamette Valley Cancer Center

    Eugene, Oregon, 97401, United States

  • Woman's Hospital

    Baton Rouge, Louisiana, 70817, United States

  • Women and Infants Hospital

    Providence, Rhode Island, 02905, United States

  • Women's Cancer Care-Covington

    Covington, Louisiana, 70433, United States

  • Women's Cancer Center of Nevada

    Las Vegas, Nevada, 89106, United States

  • Women's Cancer Center of Seattle

    Seattle, Washington, 98133, United States

  • Woodland Memorial Hospital

    Woodland, California, 95695, United States

  • Wright-Patterson Medical Center

    Wright-Patterson Air Force Base, Ohio, 45433, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

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