New dissolving nasal dressing could improve sinus surgery recovery
NCT ID NCT07286201
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a new biodegradable nasal dressing that slowly releases a steroid (mometasone furoate) to a standard steroid-releasing stent, both used after sinus surgery. About 110 adults with chronic sinusitis (with or without nasal polyps) will receive the new dressing in one nostril and the standard stent in the other. The goal is to see if the new dressing is as safe and effective at promoting wound healing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mometasone furoate
- What this could lead to
- If successful, this could offer a safer, absorbable alternative to current steroid stents for improving healing after sinus surgery.
- What could go wrong
- This is an early-stage, non-randomized comparison with only 110 participants. The dressing may not prove superior or could have unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 110 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subject is 18 years or older 2. Subject is scheduled to undergo bilateral endoscopic sinus surgery for Chronic Rhinosinusitus with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP) and is indicated for bilateral complete ethmoidectomy (anterior and posterior ethmoidectomy) at a minimum. Additional sinuses may be operated on at the surgeon's discretion. 3. Subject is willing and able to provide informed consent. 4. Subject is willing and able to comply with the investigational plan requirements. 5. Subjects with a pre-operative Lund-MacKay stage of 6 (≥3 per nostril). 6. Subject with a pre-operative Lund-Mackay stage side-to-side difference ≤ 2. 7. Subject of child-bearing potential is not pregnant and agrees to not become pregnant during the course of the study. Exclusion Criteria: 1. Subject with a history of chronic epistaxis or experienced a significant epistaxis event (defined as epistaxis requiring medical intervention) in the past 3 months. 2. Subject with an underlying systemic disorders known to affect the nose (e.g., Wegener's granulomatosis, sarcoidosis, Churg-Strauss syndrome, or other systemic vasculitides). 3. Subject with any bleeding disorder or use of medication increasing bleeding risk, except low-dose aspirin. 4. Subject with a known or suspected allergy to device components. 5. Subject with known hemophilia. 6. Subject with insulin dependent diabetes. 7. Subject with an oral steroid dependent condition. 8. Subject with glaucoma, ocular hypertension, posterior subcapsular cataracts. 9. Subject with a (previous) diagnosis of Samter's Triad (AERD). 10. Subject that requires nasal ointments or creams at time of device placement. 11. Subject with a neurological, medical, psychiatric condition, or social circumstance that would potentially increase risk, interfere with study participation, or confound interpretation of study data. 12. Subject with plans to (or otherwise anticipate the need to) undergo an ENT procedure within the 90-day study follow-up. 13. Subject participating in another clinical research study (within 30 days prior to screening up to 90 days post-operative). 14. Subject that used any form of biologics within 90 days prior to sinus surgery and during follow-up to day 25. 15. Subject that used any form of corticosteroid within 2 weeks prior to sinus surgery.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
9 sites. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centers for Advanced ENT Care
Towson, Maryland, 21204, United States
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Colorado ENT & Allergy
Colorado Springs, Colorado, 80923, United States
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ENT Allergy & Associates
Puyallup, Washington, 98374, United States
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Emory University
Atlanta, Georgia, 30308, United States
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Louisiana State University Health at Shreveport
Shreveport, Louisiana, 71103, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Ogden Clinic
Ogden, Utah, 84403, United States
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University of Illinois at Chicago
Chicago, Illinois, 60612, United States
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University of Texas Health
Houston, Texas, 77030, United States
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