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New dissolving nasal dressing could improve sinus surgery recovery

NCT ID NCT07286201

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new biodegradable nasal dressing that slowly releases a steroid (mometasone furoate) to a standard steroid-releasing stent, both used after sinus surgery. About 110 adults with chronic sinusitis (with or without nasal polyps) will receive the new dressing in one nostril and the standard stent in the other. The goal is to see if the new dressing is as safe and effective at promoting wound healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mometasone furoate
What this could lead to
If successful, this could offer a safer, absorbable alternative to current steroid stents for improving healing after sinus surgery.
What could go wrong
This is an early-stage, non-randomized comparison with only 110 participants. The dressing may not prove superior or could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Subject is 18 years or older 2. Subject is scheduled to undergo bilateral endoscopic sinus surgery for Chronic Rhinosinusitus with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP) and is indicated for bilateral complete ethmoidectomy (anterior and posterior ethmoidectomy) at a minimum. Additional sinuses may be operated on at the surgeon's discretion. 3. Subject is willing and able to provide informed consent. 4. Subject is willing and able to comply with the investigational plan requirements. 5. Subjects with a pre-operative Lund-MacKay stage of 6 (≥3 per nostril). 6. Subject with a pre-operative Lund-Mackay stage side-to-side difference ≤ 2. 7. Subject of child-bearing potential is not pregnant and agrees to not become pregnant during the course of the study. Exclusion Criteria: 1. Subject with a history of chronic epistaxis or experienced a significant epistaxis event (defined as epistaxis requiring medical intervention) in the past 3 months. 2. Subject with an underlying systemic disorders known to affect the nose (e.g., Wegener's granulomatosis, sarcoidosis, Churg-Strauss syndrome, or other systemic vasculitides). 3. Subject with any bleeding disorder or use of medication increasing bleeding risk, except low-dose aspirin. 4. Subject with a known or suspected allergy to device components. 5. Subject with known hemophilia. 6. Subject with insulin dependent diabetes. 7. Subject with an oral steroid dependent condition. 8. Subject with glaucoma, ocular hypertension, posterior subcapsular cataracts. 9. Subject with a (previous) diagnosis of Samter's Triad (AERD). 10. Subject that requires nasal ointments or creams at time of device placement. 11. Subject with a neurological, medical, psychiatric condition, or social circumstance that would potentially increase risk, interfere with study participation, or confound interpretation of study data. 12. Subject with plans to (or otherwise anticipate the need to) undergo an ENT procedure within the 90-day study follow-up. 13. Subject participating in another clinical research study (within 30 days prior to screening up to 90 days post-operative). 14. Subject that used any form of biologics within 90 days prior to sinus surgery and during follow-up to day 25. 15. Subject that used any form of corticosteroid within 2 weeks prior to sinus surgery.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    9 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centers for Advanced ENT Care

    Towson, Maryland, 21204, United States

  • Colorado ENT & Allergy

    Colorado Springs, Colorado, 80923, United States

  • ENT Allergy & Associates

    Puyallup, Washington, 98374, United States

  • Emory University

    Atlanta, Georgia, 30308, United States

  • Louisiana State University Health at Shreveport

    Shreveport, Louisiana, 71103, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Ogden Clinic

    Ogden, Utah, 84403, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60612, United States

  • University of Texas Health

    Houston, Texas, 77030, United States

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