Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New eye drug IZERVAY under Real-World watch: will it slow vision loss?

NCT ID NCT06779773

Knowledge-focused Sponsor: Astellas Pharma Global Development, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 18, 2026 · Updated 8 times

Summary

This study follows 500 people with geographic atrophy, an advanced form of age-related macular degeneration that causes permanent vision loss. Participants receive avacincaptad pegol (IZERVAY) as part of their routine care. Researchers will collect data on treatment patterns, side effects, and patient-reported outcomes over up to 5 years to see how the drug performs in real-world settings.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
avacincaptad pegol (IZERVAY)
What this could lead to
If successful, this study could provide valuable information on how avacincaptad pegol works in everyday medical practice, helping doctors better manage geographic atrophy.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by differences in patient care and may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Oct 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants from both academic and non-academic sites, urban and rural across the US to ensure a heterogenous population that is representative of the US GA secondary to AMD population and reflective of real-world practice patterns.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in 1 or both eyes * Patient with a decision to treat with intravitreal avacincaptad pegol (ACP) prior to enrollment * Patient willingness to complete the patient reported outcome (PRO). Exclusion Criteria: * Patients who have any contraindication or are not eligible for treatment with ACP, including the following: * Active ocular or peri-ocular infection in either eye * Active, suspected intraocular inflammation in either eye * Hypersensitive to ACP or to any ingredient in the formulation * Patients currently participating in an investigational program with interventions outside of routine clinical practice. * Patients who have received ACP in the eye being considered for enrollment. Note: Patients who have received or are receiving ACP in the fellow eye at baseline are eligible to be included in the study. * Patients who have received any intravitreal complement inhibitor other than ACP in either eye. Note: Patients who have received an intravitreal complement inhibitor other than ACP in either eye and have completed the 90-day washout period are eligible to be included in the study.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Geographic atrophy are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

age-related macular degeneration dry age related macular degeneration Geographic Atrophy macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Geographic atrophy Macular degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    55 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Advanced Retina Institute

    RECRUITING

    Bonita Springs, Florida, 34134, United States

  • Brown Family Retina PLLC

    RECRUITING

    Olive Branch, Mississippi, 38654, United States

  • CEI Physicians PSC, LLC dba

    RECRUITING

    Dayton, Ohio, 45459, United States

  • Coastal Eye Surgeons

    RECRUITING

    Greenwich, Connecticut, 05830, United States

  • Colorado Retina Associates, PLLC

    RECRUITING

    Lakewood, Colorado, 80228, United States

  • Cumberland Valley Retina Consultants,P.C.

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • Deep Blue Retina Clinical Research

    RECRUITING

    Southaven, Mississippi, 38671, United States

  • Erie Retina Research

    RECRUITING

    Erie, Pennsylvania, 16507, United States

  • Eye Associates of North Jersey PA

    RECRUITING

    Dover, New Jersey, 07801, United States

  • Eye Physicians of Pinellas PA dba Eye Institute of West Florida

    RECRUITING

    Tampa, Florida, 33606, United States

  • Florida Eye Clinic

    WITHDRAWN

    Altamonte Springs, Florida, 32701, United States

  • Harvard Eye Associates

    RECRUITING

    Laguna Hills, California, 92653, United States

  • Illinois Eye Center

    RECRUITING

    Peoria, Illinois, 61615, United States

  • Illinois Retina Associates

    RECRUITING

    Oak Park, Illinois, 60304, United States

  • Long Island Vitreoretinal Consultants

    RECRUITING

    Scarsdale, New York, 10583, United States

  • Medical Center Ophthalmology Associates

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Mid South Retina Associates

    RECRUITING

    Memphis, Tennessee, 38119, United States

  • Mississippi Retina Associates

    RECRUITING

    Madison, Mississippi, 39110, United States

  • Monmouth Retina Consultants

    WITHDRAWN

    Little Silver, New Jersey, 07739, United States

  • NJ Retina

    RECRUITING

    Edison, New Jersey, 08820, United States

  • NJ Retina

    RECRUITING

    Lakewood, New Jersey, 08701, United States

  • NJ Retina

    RECRUITING

    Toms River, New Jersey, 08755, United States

  • NY Retina Ophthalmology PLLC

    ACTIVE_NOT_RECRUITING

    Massapequa, New York, 11758, United States

  • North Carolina Retina Associates

    WITHDRAWN

    Cary, North Carolina, 27511, United States

  • North Carolina Retina Associates

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

  • Phoenix Retina Clinical Trials, LLC

    WITHDRAWN

    Phoenix, Arizona, 85050, United States

  • Piedmont Eye Center, Inc.

    RECRUITING

    Lynchburg, Virginia, 24502, United States

  • Retina & Vitreous Consultants of Wisconsin

    ACTIVE_NOT_RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Retina & Vitreous of Texas

    WITHDRAWN

    Bellaire, Texas, 77401, United States

  • Retina Associates Of South Texas, Pa

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Retina Associates of Michigan

    RECRUITING

    Grand Blanc, Michigan, 48439, United States

  • Retina Associates of New York

    ACTIVE_NOT_RECRUITING

    New York, New York, 10075, United States

  • Retina Associates of Utah, P.C.

    RECRUITING

    Murray, Utah, 84107, United States

  • Retina Care Specialists

    RECRUITING

    Palm Beach Gardens, Florida, 33410, United States

  • Retina Consultants of Minnesota PLLC

    RECRUITING

    Saint Louis Park, Minnesota, 55416, United States

  • Retina Consultants of Southern CA

    RECRUITING

    Redlands, California, 92374, United States

  • Retina Consultants of Southern Colorado

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

  • Retina Macula Institute

    RECRUITING

    Torrance, California, 90503, United States

  • Retina Macula Institute of Arizona

    RECRUITING

    Scottsdale, Arizona, 85255, United States

  • Retina Research Institute of Texas

    RECRUITING

    Abilene, Texas, 79606, United States

  • Retina Specialists

    WITHDRAWN

    Towson, Maryland, 21204, United States

  • Retina Specialists of Tampa

    RECRUITING

    Wesley Chapel, Florida, 33544, United States

  • Retina of North Texas

    RECRUITING

    Dallas, Texas, 75243, United States

  • Retina-Vitreous Surgeons of Central NY

    RECRUITING

    Liverpool, New York, 13088, United States

  • Retinal Consultants Medical Group Inc

    RECRUITING

    Sacramento, California, 95825, United States

  • Retinal Consultants of AZ

    RECRUITING

    Phoenix, Arizona, 85053, United States

  • Rocky Mountain Lions Eye Institute

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Salt Lake Retina

    RECRUITING

    Salt Lake City, Utah, 84120, United States

  • Sierra Eye Associates

    RECRUITING

    Reno, Nevada, 89502, United States

  • SightMD

    RECRUITING

    Brentwood, New York, 11717, United States

  • Southeast Retina Center, P.C.

    RECRUITING

    Augusta, Georgia, 30909, United States

  • Southeastern Retina Associates, P.C.

    RECRUITING

    Knoxville, Tennessee, 37920, United States

  • Southeastern Retina Associates, P.C.

    RECRUITING

    Knoxville, Tennessee, 37923, United States

  • Tennessee Retina, PC

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • The Ohio State University

    RECRUITING

    Columbus, Ohio, 43221, United States

  • The Retina Group of Washington

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • The Retina Partners

    WITHDRAWN

    Encino, California, 91436, United States

  • University Retina and Macula Associates, P.C.

    RECRUITING

    Oak Forest, Illinois, 60452, United States

  • University of California Irvine Medical Center

    RECRUITING

    Orange, California, 92868, United States

  • University of Miami

    RECRUITING

    Coral Gables, Florida, 33146, United States

  • Valley Retina Institute

    RECRUITING

    McAllen, Texas, 78503, United States

  • Verum Research, LLC

    RECRUITING

    Eugene, Oregon, 97401, United States

  • Virginia Retina Center

    RECRUITING

    Warrenton, Virginia, 20186, United States

  • Vitreoretinal Consultants

    RECRUITING

    Shirley, New York, 11967, United States

  • Wolfe Eye Clinic

    RECRUITING

    West Des Moines, Iowa, 50266, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.