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Scientists probe muscle protein changes in obesity to unlock health secrets

NCT ID NCT04700800

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how exercise and amino acid infusions change muscle protein production in people with obesity. Researchers measured how fast different muscle proteins were made in 48 volunteers. The goal was to understand why obesity alters muscle fiber types, which may lead to better ways to manage muscle health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise and amino acid infusion
What this could lead to
If successful, this could help explain why obesity changes muscle composition and point toward ways to improve muscle health in people with obesity.
What could go wrong
This is a small, early-stage study focused on understanding basic biology, not testing a treatment. Results may not lead to direct health benefits or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Oct 2021

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ability to sign informed consent form * body mass index (BMI), 18-26 kg/m2 (lean subjects), 32-50 kg/m2 (subjects with obesity) Exclusion Criteria: * prescription or over-the-counter medication * supplements known to affect protein metabolism (i.e., amino acids, protein, omega-3 fatty acids) * diabetes * acute illness * liver disease * uncontrolled metabolic disease, including renal disease * heart disease related to atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure or ECG documented abnormalities * low hemoglobin or hematocrit * use of anabolic steroids or corticosteroids (within 3 months) * not classified as inactive/sedentary based on the Stanford Brief Activity Survey and accelerometry data * participation in a weight-loss regimen * extreme dietary practices (i.e., vegan, vegetarian) * smoking * pregnancy * gastro-intestinal surgery * any other condition or event considered exclusionary by the PI and the study physician.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.