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Cure My Disease

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New weekly injection could help fight obesity

NCT ID NCT07339423

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This study tests a new drug called NNC0487-0111, given as a once-weekly injection, to see if it helps people with obesity lose weight safely. About 1,150 adults who have tried to lose weight before will receive either the drug or a placebo. The main goal is to measure how much body weight they lose over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NNC0487-0111 (a once-weekly injection for weight loss)
What this could lead to
If it works, this could offer a new once-weekly treatment option for obesity, helping people lose weight and improve health.
What could go wrong
This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is not a cure for obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Male or female (sex at birth). * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * History of at least one self-reported unsuccessful dietary effort to lose body weight. Key Exclusion Criteria: * HbA1c ≥ 6.5% (48 millimole per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    71 sites in 9 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AZ Delta - Roeselare

    RECRUITING

    Roeselare, 8800, Belgium

  • Accellacare and KDCILM, LLC

    RECRUITING

    Wilmington, North Carolina, 28401, United States

  • Albany House Medical Centre

    RECRUITING

    Wellingborough, NN8 4RW, United Kingdom

  • Amarillo Medical Specialists

    RECRUITING

    Amarillo, Texas, 79124, United States

  • C-Health Partners

    RECRUITING

    Calgary, Alberta, T2V 4J2, Canada

  • CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques

    RECRUITING

    Vénissieux, 69200, France

  • CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL-Service de diabétologie et nutrition

    RECRUITING

    Toulouse, 31059, France

  • CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition

    RECRUITING

    Saint-Herblain, 44800, France

  • CIPADI

    RECRUITING

    Godoy Cruz, M5501ARP, Argentina

  • Care United Research, LLC

    RECRUITING

    Forney, Texas, 75126, United States

  • Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli

    RECRUITING

    Buenos Aires, C1425AGC, Argentina

  • Clifton Medical Centre

    RECRUITING

    Rotherham, S65 1DA, United Kingdom

  • Clinical Neuroscience Solution

    RECRUITING

    Orlando, Florida, 32801, United States

  • Clinical Res Collaborative

    RECRUITING

    Cumberland, Rhode Island, 02864, United States

  • Coastal Carolina Research Ctr

    RECRUITING

    North Charleston, South Carolina, 29405, United States

  • EMS Healthcare

    RECRUITING

    Cheshire, CH65 4LE, United Kingdom

  • Endeavor Health

    RECRUITING

    Skokie, Illinois, 60077, United States

  • Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann

    RECRUITING

    Witten, 58455, Germany

  • Fowey River Practice

    RECRUITING

    Fowey, Cornwall, PL23 1DT, United Kingdom

  • Fundación CESIM

    RECRUITING

    Santa Rosa, La Pampa Province, 6300, Argentina

  • G.A. Research Associates Ltd.

    RECRUITING

    Moncton, New Brunswick, E1G 1A7, Canada

  • Gentofte Hospital - Center for Klinisk Metabolisk Forskning

    RECRUITING

    Hellerup, 2900, Denmark

  • HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition

    RECRUITING

    Pierre-Bénite, 69310, France

  • HMC Health - Heston - The Meadows Centre for Health

    RECRUITING

    Hounslow, TW4 7NJ, United Kingdom

  • HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie

    RECRUITING

    Paris, 75015, France

  • HUB - Hôpital Erasme

    RECRUITING

    Brussels, 1070, Belgium

  • Health Res of Hampton Roads

    RECRUITING

    Newport News, Virginia, 23606, United States

  • Heart of Australia

    RECRUITING

    Chelmer, Queensland, 4068, Australia

  • Herz- und Diabeteszentrum NRW - Bad Oeynhausen

    RECRUITING

    Bad Oeynhausen, 32545, Germany

  • Hillcrest Clinical Research

    RECRUITING

    Simpsonville, South Carolina, 29681-1538, United States

  • Hillerød Endokrinologisk amb. H0652

    RECRUITING

    Hillerød, 3400, Denmark

  • Hope Clin Res & Wellness

    RECRUITING

    Conyers, Georgia, 30094, United States

  • Hunter Diabetes Centre

    RECRUITING

    Merewether, New South Wales, 2291, Australia

  • Hvidovre Hospital Endokrinologisk forsknings afsnit 159

    RECRUITING

    Hvidovre, 2650, Denmark

  • Institut für Diabetesforschung Osnabrück

    RECRUITING

    Osnabrück, 49080, Germany

  • Instituto de Investigaciones Clinicas San Nicolás

    RECRUITING

    San Nicolás, B2900, Argentina

  • Instituto de Investigaciones Clínicas Córdoba

    RECRUITING

    Córdoba, 5000, Argentina

  • Kiltearn Medical Centre

    RECRUITING

    Nantwich, CW5 5NX, United Kingdom

  • Knowle House Surgery

    RECRUITING

    Plymouth, PL5 3JB, United Kingdom

  • MECLINAS

    RECRUITING

    Mechelen, 2800, Belgium

  • MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien

    RECRUITING

    Fulda, 36037, Germany

  • Medical Uni of SC Charleston

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Midwest Inst For Clin Res

    RECRUITING

    Indianapolis, Indiana, 46260, United States

  • Milestone Research

    RECRUITING

    London, Ontario, N5W 6A2, Canada

  • New York Gastroenterology Associates

    RECRUITING

    New York, New York, 10075, United States

  • Nova Scotia Hlth Halifax

    RECRUITING

    Halifax, Nova Scotia, B3H1V7, Canada

  • Ocean West Research Clinic

    RECRUITING

    Surrey, British Columbia, V3Z 2N6, Canada

  • PharmQuest Life Sciences LLC

    RECRUITING

    Greensboro, North Carolina, 27408, United States

  • Pickering Medical Practice

    RECRUITING

    Pickering, North Yorkshire, YO18 8BL, United Kingdom

  • Rainier Clin Res Ctr Inc

    RECRUITING

    Renton, Washington, 98057, United States

  • SMO.MD GmbH - Zentrum für klinische Studien

    RECRUITING

    Magdeburg, 39120, Germany

  • Sanatorio Esperanza

    RECRUITING

    Esperanza, Santa Fe, S3080BQV, Argentina

  • Sanos Clinic - Gandrup

    RECRUITING

    Gandrup, 9362, Denmark

  • Sanos Clinic - Vejle

    RECRUITING

    Vejle, Region Syddanmark, 7100, Denmark

  • Selma Medical Associates

    RECRUITING

    Winchester, Virginia, 22601-3834, United States

  • South Broward Research LLC

    RECRUITING

    Miramar, Florida, 33027, United States

  • Staploe Medical Centre

    RECRUITING

    Soham, CB7 5JD, United Kingdom

  • Steno Diabetes Center Nordjylland

    COMPLETED

    Gistrup, 9260, Denmark

  • StudyMetrix Research LLC

    RECRUITING

    City of Saint Peters, Missouri, 63303, United States

  • Sydney Cardiometabolic Centre

    RECRUITING

    Liverpool, New South Wales, 2170, Australia

  • Sydney Clinical Trials

    RECRUITING

    Campbelltown, New South Wales, 2560, Australia

  • The Adam Practice

    RECRUITING

    Poole, Dorset, BH16 5PW, United Kingdom

  • The Crouch Oak Family Practice

    RECRUITING

    Addlestone, Surrey, KT15 2BH, United Kingdom

  • The Health Centre

    RECRUITING

    Bradford-on-Avon, BA15 1DQ, United Kingdom

  • UNC Eastowne Medical Office

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

  • UPA Ctr Weight and Eating Dis

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • UZ Leuven - Endocrinology

    RECRUITING

    Leuven, 3000, Belgium

  • UZA - UZ Antwerpen - Department of Endocrinology

    RECRUITING

    Edegem, 2650, Belgium

  • Universitair Ziekenhuis Gent

    RECRUITING

    Ghent, 9000, Belgium

  • Velocity Clinical Res-Dallas

    RECRUITING

    Dallas, Texas, 75230-6855, United States

  • Washington Cntr Weight Mgmt

    RECRUITING

    Arlington, Virginia, 22206, United States

  • Zentrum für klinische Studien Südbrandenburg GmbH

    RECRUITING

    Elsterwerda, 04910, Germany

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Other studies related to the condition(s) this trial covers.