Can a simple change in antibiotic dosing help obese patients?
NCT ID NCT06690905
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether giving an antibiotic (piperacillin-tazobactam) as a longer infusion helps people with obesity reach the right drug levels in their blood. It included 45 hospitalized adults with a BMI of 30 or higher. The main goal was to see if a larger study is possible, not to prove the treatment works better.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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45 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults (18 years and older) * Patients hospitalized at Hôpital Charles-Le Moyne * Obesity (as defined by a body mass index of ≥ 30 kg/m\^2) * Piperacillin-tazobactam prescription initiated within last 24 hours * Planned duration of piperacillin-tazobactam of 24 hours or more Exclusion Criteria: * Documented allergy to beta-lactams of the penicillin class * Patients with renal replacement therapy (hemodialysis, peritoneal dialysis, continuous venovenous hemodiafiltration) * Pregnancy * History of seizures or epilepsy, active seizures or epilepsy treated with antiepileptic drug therapy * Patients on prolonged intermittent infusion or continuous infusion of piperacillin-tazobactam before randomization
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Charles- Le Moyne
Greenfield Park, Quebec, J4V 2H1, Canada
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