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Fish oil and protein powder: a new recipe for knee surgery recovery?

NCT ID NCT06233825

Disease control Sponsor: Dr. Chris McGlory, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether taking omega-3 fatty acids (fish oil) and essential amino acids (protein building blocks) before and after knee surgery could help prevent muscle loss. Thirty adults scheduled for ACL reconstruction took either the supplements or a placebo for 4 weeks before and 2 weeks after surgery. The main goal was to see if such a study is feasible, while also measuring muscle mass and strength changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Omega-3 fatty acids (fish oil) and essential amino acids
What this could lead to
If this approach works, it could point toward a simple nutritional supplement to help people regain muscle strength faster after knee surgery.
What could go wrong
This is a very small pilot study (30 people) focused on feasibility, not proof of effectiveness. The results may not apply to everyone, and the supplements may not provide significant benefit over standard recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Feb 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed anterior cruciate ligament injury requiring reconstruction surgery * Surgery in Kingston, ON * Patellar tendon graft, quadriceps tendon graft, or hamstring tendon graft reconstruction procedure Exclusion Criteria: * Any muscular, neurological, respiratory, or metabolic disease, subject to investigators' discernment, would negatively affect the subject's ability to comply with the study requirements * Any form of cancer currently or in the last 5 years * Bleeding disorders or antiplatelet / anticoagulation therapy * Currently taking fish oils or within the last 6 months * Regular consumption (≥ 2x week) of fish oil or oily fish in the last 6 months * Allergy or sensitivity to fish, shellfish or safflower oils * Currently taking any form of steroid or within the last 6 months * Medical inability to attain magnetic resonance imaging scans * Known irregular responses to physical activity (e.g., shortness of breath, chest pain, dizziness, etc.) * Surgery scheduled outside of research centre * Scheduled surgery date \< 5 weeks away * Pregnant or plans to become pregnant within the next 6 months * Any current illness that impacts ability to participate in protocols

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Conditions

The condition(s) this trial relates to.

muscular atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament reconstruction Muscular atrophy

Contacts and locations

Locations

  • Queen's University

    Kingston, Ontario, K7L 3N6, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.