Simple nurse-led plan may stop deadly clots after neurosurgery
NCT ID NCT07330661
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed trial tested whether a nurse-led program of early movement, leg-sleeve squeezes, and blood tests could prevent deep vein thrombosis (DVT) in adults after brain or spine surgery. Over 1,200 participants were randomly assigned to either the nurse-led program or standard hospital care. The goal was to see if the program lowers the number of clots within 30 days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nurse-led program (early movement, leg-sleeve squeezes, and blood tests)
- What this could lead to
- If it works, this could give hospitals a simple, low-cost way to prevent blood clots after neurosurgery, reducing complications and saving lives.
- What could go wrong
- This is a completed trial, but results are not yet widely known. The program may not reduce clots significantly more than standard care, and the findings may not apply to all hospitals or patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
1,286 people
The number who actually took part.
- Started
-
Jan 2021
- Finished
-
May 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Age ≥ 18 years * Any elective or emergency craniotomy, spinal, or other neurosurgical procedure * Expected post-operative hospital stay ≥ 3 days * Patient or legally authorized representative willing and able to give written informed consent Exclusion Criteria * Pre-operative ultrasound or imaging proven DVT or pulmonary embolism * Known hereditary bleeding disorder (e.g., hemophilia) or platelet count \< 50 × 10⁹/L * Chronic therapeutic anticoagulation (warfarin, DOAC, heparin) that cannot be safely stopped, or need for full-dose post-op anticoagulation * Severe liver disease (Child-Pugh class C) or eGFR \< 30 mL/min/1.73 m² * Life-limiting co-morbidity with expected survival \< 30 days * Pregnancy or breastfeeding * Current participation in another interventional VTE trial
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Deep vein thrombosis (DVT) are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
West China Hospital of Sichuan University
Chengdu, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a tiny device suction out dangerous blood clots?
- Could a 30-Day blood thinner regimen prevent clots after spine cancer surgery?
- New tool aims to help blood clot patients choose wisely on blood thinners
- New device could make DVT monitoring safer and simpler
- Blood clot prevention: which strategy saves most lives and money?
- AI may predict dangerous clots after lung cancer surgery