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Common painkillers may alter key protein in back pain patients

NCT ID NCT07662668

Knowledge-focused Sponsor: Keimyung University Dongsan Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 19, 2026 · Updated 5 times

Summary

This study looks at whether taking NSAIDs (like ibuprofen) changes the level of a protein called periostin in the blood of people with degenerative disc disease. Researchers will compare three groups: patients using NSAIDs, patients not using NSAIDs, and healthy people without back pain. The goal is to better understand how inflammation and tissue repair work in this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-steroidal anti-inflammatory drug (NSAID)
What this could lead to
If successful, this could show that NSAIDs lower periostin levels, pointing toward a biomarker to guide treatment for disc disease.
What could go wrong
This is an early observational study, not a treatment trial. It only measures blood markers, so it cannot prove that NSAIDs improve symptoms or slow disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 144 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

low back pain population with disc degeneration confirmed in MRI

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * lumbar disc herniation * lumbar spinal canal stenosis * patients who have MRI Exclusion Criteria: * allergic disease * allergic rhinitis * asthma * atopic dermatitis * chronic sinusitis * history of cancer * fracture within 6 months * severe osteoporosis * knee osteoarthritis * hip osteoarthritis * spinal surgery within 6 months * myocardiac infarction * heart failure * liver cirrhosis * chronic kidney disease * rheumatoid disease * systemic lupus erythematosus * ankylosing spondylitis * Crohn's disease * Ulcerative colitis * systemic steroid user * acute or chronic infection * BMI \> 30 * uncontrolled hypertension * uncontrolled diabetes * recent hisory vaccination

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Conditions

The condition(s) this trial relates to.

lumbar disk degenerative disorder lumbar disk herniation, susceptibility to lumbar spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intervertebral disc disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hong Ji Hee

    RECRUITING

    Daegu, South Korea

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