Can prism training and electrical stimulation help stroke survivors see and walk better?
NCT ID NCT06053320
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether combining prism adaptation training with electrical stimulation can help people who have had a stroke and have spatial neglect (trouble noticing things on one side). Researchers will measure changes in pointing behavior, brain activity, and walking ability. The study includes 65 participants: healthy young adults, healthy older adults, and stroke survivors.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 65 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2023
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Young Adults Able Bodied (YAB) Individuals * 18-30 years * Able-Bodied (healthy without any physical disability or neurological disorder) Older Adults Able-Bodied Individuals (OAB) * 45-90 years * Able-Bodied (healthy without any physical disability or neurological disorder) Individuals with right hemisphere stroke (40-90 years) * \>3 months following stroke. * Presence of Aiming SN * Ability to walk \>10m with or without assistive devices. * Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale * Ability to follow 3-stage commands and provide informed consent. Exclusion Criteria: Young Adults Able-Bodied (YAB) Individuals and Older Adults Able-Bodied Individuals (OAB) * History or evidence of orthopedic or physical disability * History or evidence of neurological pathology * Pregnancy (female) * Uncontrolled hypertension * Cardiac pacemaker or other implanted electronic system * Presence of skin conditions preventing the electrical stimulation setup * Impaired sensation in the left upper limb. * Bruises or cuts at the stimulation electrode placement site * Concurrent enrollment in rehabilitation or another investigational study. * History or evidence of orthopedic or physical disability interfering with study procedures * History or evidence of neurological pathology or disorder * Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures * Contraindications to TMS, such as metal implants, medications that can increase cortical excitability, and unexplained dizziness in the past 6 months Individuals with right hemisphere stroke (40-90 years) * History or brainstem strokes * Cerebellar disorders * Impaired sensation in the left upper limb. * History of other neurological disorders * Uncontrolled hypertension * Cardiac pacemaker or other implanted electronic system * Pregnancy (female) * Presence of skin condition * Bruises at the electrode placement site * Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures * Contraindications to TMS, such as metal implants in the brain, medications that will increase cortical excitability, etc.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Emory Rehabilitation Hospital
RECRUITINGAtlanta, Georgia, 30322, United States
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Emory University Hospital (EUH)
RECRUITINGAtlanta, Georgia, 30322, United States
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Executive Park
RECRUITINGAtlanta, Georgia, 30329, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
- Zapping the spine while wearing a robotic ankle: a new way to help kids walk?
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- Can PET scans reveal hidden heart inflammation after a stroke?
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