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E-Cig study: does less nicotine mean less harm?

NCT ID NCT06619964

Knowledge-focused Sponsor: Rochester Institute of Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study follows 120 adult e-cigarette users for two weeks to see if those who use lower nicotine e-liquids have less nicotine exposure and fewer harmful chemicals compared to those using higher nicotine e-liquids. Participants will use their usual devices at home, complete daily surveys, and provide saliva, urine, and blood samples. The goal is to inform future regulations on nicotine content in e-liquids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could provide evidence to guide regulations on nicotine levels in e-liquids, potentially reducing harm for e-cigarette users.
What could go wrong
This is an observational study, not a treatment trial, so it cannot prove cause and effect. Results may not apply to all e-cigarette users or devices.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Residence of the Greater Rochester, NY area

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 21 yrs or older * Pod-style or pen-style users, not adjustable for power or airflow, nicotine greater than 0 mg/mL * Current everyday users * Use history of at least 30 days * No current use of combustible tobacco product, or nicotine replacement therapy * CO less than 6 ppm at intake * No plans to quit tobacco use in the next 30 days Exclusion Criteria: * History of acute or chronic asthma * Previous diagnosis of cancer * Other chronic medical conditions * Use of chronic prescription medications * Pneumonia in prior six weeks * Upper respiratory tract infection or other febrile illness in previous 2 weeks * On antioxidants or anti-inflammatory therapy * Pregnant women or women who intend to become pregnant

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Conditions

The condition(s) this trial relates to.

nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nicotine addiction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rochester Institute of Technology

    Rochester, New York, 14623, United States

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