Space-Age supplement study: can nicotinamide riboside shield astronauts from tylenol toxicity?
NCT ID NCT06214468
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a dietary supplement called nicotinamide riboside (NR) can reduce the harmful effects of acetaminophen (like Tylenol). Researchers measured chemicals in the blood and urine of 26 healthy volunteers after taking acetaminophen alone or with NR. They also tested blood under conditions that mimic space travel. The goal was to understand how acetaminophen causes cell damage and whether NR can help protect against it.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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26 people
The number who actually took part.
- Started
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Jan 2024
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * n/a Exclusion Criteria: * Individual allergic to acetaminophen or nicotinamide riboside
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of South Alabama
Mobile, Alabama, 36604, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.