Promising new combo therapy targets hard-to-treat lymphoma

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Age ≥18 years; Pathologically confirmed diagnosis of relapsed or refractory DLBCL; Patients must meet the following criteria: 1. Definition of relapsed or refractory: Refractory: Patients who did not achieve remission (≥PR) with the most recent systemic therapy; Relapsed/progressive: Patients who developed new lesions or experienced a ≥50% increase in existing lesions (based on the Lugano 2014 classification for non-Hodgkin lymphoma) following the most recent systemic therapy; 2. At least one bidimensionally measurable lesion, defined as a lesion with the longest dimension \>1.5 cm and perpendicular diameter \>1.0 cm on contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI), confirmed as positive by PET-CT; 3. For DLBCL, prior receipt of at least one line but no more than four lines of systemic therapy, which must include CD20-targeted therapy; 4. ECOG performance status score of 0-2. Meet the criteria for autologous hematopoietic stem cell transplantation (ASCT) and be willing to undergo ASCT; Adequate major organ function: 1. Liver function: ALT/AST \<3× upper limit of normal (ULN) and total bilirubin ≤34.2 μmol/L; 2. Renal function: Creatinine \<220 μmol/L; 3. Pulmonary function: Oxygen saturation ≥95% without supplemental oxygen; 4. Cardiac function: Left ventricular ejection fraction (LVEF) ≥40%; 5. Transplant comorbidity index score ≤3. As judged by the investigator, patients must: 1. Be willing to receive adequate prophylaxis and/or treatment for thromboembolic events; 2. Be able to understand and sign informed consent, and comply with all study-related procedures, medication use, and evaluations; 3. Have no history of non-adherence to medical prescriptions or be deemed by the investigator to have no potential for non-adherence; 4. Be able to understand and comply with pregnancy prevention requirements and reasons, the pregnancy prevention risk management plan, and provide written confirmation. Exclusion Criteria Pregnant (positive urine/serum pregnancy test) or lactating women; Men or women with plans for conception within 1 year; Inability to guarantee effective contraceptive measures (e.g., condoms, contraceptives) within 1 year after enrollment; Uncontrolled infectious disease within 4 weeks prior to enrollment; Active hepatitis B or C virus infection; Severe autoimmune disease or immunodeficiency disorder; History of allergy to macromolecular biologic drugs such as antibodies or cytokines; Participation in another clinical trial within 6 weeks prior to enrollment; Systemic use of corticosteroids within 4 weeks prior to enrollment (excluding patients using inhaled corticosteroids); Psychiatric illness; Substance abuse/dependence; Any other condition that, in the investigator's judgment, makes the patient unsuitable for enrollment.