Can a new drug combo outperform standard chemo for Hard-to-Treat lymphoma?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The subject has been fully informed and is willing to sign the Informed Consent Form (ICF). 2. Age is ≥18 years and ≤75 years, both men and women are eligible. 3. Pathologically diagnosed as diffuse large B-cell lymphoma according to the 2022 World Health Organization classification, confirmed by central pathology review (Patients who relapse after more than one year need to undergo tissue biopsy again to confirm the pathological diagnosis.). 4. Measurable lesions \[The criteria for measurable lesions are: the longest diameter of lymph node lesions measured by enhanced Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) is greater than 15 mm, and the longest diameter of extranodal lesions is greater than 10 mm.\] assessed by Positron Emission Tomography/Computed Tomography (PET-CT) and Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) according to the Lugano 2014 criteria . 5. Must have relapsed or refractory diffuse large B-cell lymphoma after at least one systemic therapy \[Salvage chemotherapy and immunotherapy after stem cell transplantation will be considered as first-line systemic treatment; maintenance therapy will not be counted as a separate line of systemic treatment; local radiotherapy for diffuse large B-cell lymphoma (DLBCL) aimed at cure will not be counted as first-line systemic treatment; patients who do not achieve PR after four cycles of first-line treatment are eligible for the study; patients who do not achieve PR after two cycles of second-line or higher treatment are eligible for the study. Primary refractory DLBCL patients are defined as those who have no response during first-line treatment or relapse within six months after the end of treatment, and they will be allowed to participate in the study. Patients who relapse within 12 months after stem cell transplantation are also eligible for inclusion. Refractory DLBCL patients are those who do not achieve response after adequate front-line treatment (at least four cycles of first-line chemotherapy, or at least two cycles of subsequent treatment), or who progress during previous first-line treatment, or who progress within six months (less than six months) after achieving response to previous adequate front-line treatment, or who relapse within 12 months after achieving response to stem cell transplantation. Relapsed DLBCL patients are those who relapse six months or more after achieving response to previous adequate front-line treatment, or who relapse 12 months or more after achieving response to stem cell transplantation.\], and at least one systemic therapy must include CD20 antibody. 6. Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2. 7. Expected survival \>12 weeks. 8. Organ function levels must meet the following requirements: Peripheral blood: 1. Absolute neutrophil count (ANC) ≥1.0×10\^9/L; 2. Hemoglobin (HGB) ≥80g/L; 3. Platelet count (PLT) ≥100×10\^9/L; Liver and kidney function: 1. Serum total bilirubin ≤1.5×Upper Limit of Normal (ULN) (for patients with Gilbert syndrome, total bilirubin \<3.0×ULN with direct bilirubin within normal range); 2. Serum creatinine \<1.5×ULN; 3. Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) ≤2.5×ULN (≤5×ULN if there is liver involvement). Exclusion Criteria: 1. Known severe allergy to the study drug or any of its excipients; 2. Due to the potential genotoxicity, mutagenicity, and teratogenicity of the study drug, the following subjects should be excluded: 1. Men and women who have not undergone in vitro preservation of sperm or oocytes and plan to have children within 5 years, unless subsequent studies confirm reproductive safety; 2. Pregnant or breastfeeding women; 3. Primary central nervous system lymphoma; 4. DLBCL with active central nervous system brain metastases or meningeal involvement at the time of screening; 5. Other active malignant tumors that require treatment and may interfere with the study. 6. Treatment history before the trial: 1. Received other small molecule targeted drug therapy within 2 weeks before enrollment; 2. Previously received BEBT-908 or R-ICE and R-GemOx therapy before enrollment; 3. Underwent autologous hematopoietic stem cell transplantation within 3 months before enrollment; 4. Received radiotherapy that affects the evaluation of the efficacy of this study within 3 months before enrollment, or local supportive radiotherapy that affects the subject's bone marrow function; 5. Underwent myelosuppressive chemotherapy or biological therapy within 3 weeks before enrollment; 6. Used traditional Chinese medicine and patent medicine with antitumor effects within 2 weeks before enrollment; 7. Underwent major surgery (Referring to the Level 3 and Level 4 surgeries as stipulated in the "Administrative Measures for the Clinical Application of Medical Technologies" implemented on May 1, 2009.) other than tumor biopsy within 4 weeks before enrollment, or the side effects of the surgery have not yet stabilized; 8. Received any hematopoietic cell colony-stimulating factor therapy (such as granulocyte colony-stimulating factor G-CSF, granulocyte-macrophage colony-stimulating factor GM-CSF) or thrombopoietin TPO therapy (Subjects who have started receiving erythropoiesis-stimulating agents or darbepoetin within 2 weeks prior to enrollment are eligible for inclusion.) within 2 weeks before enrollment; 9. Received prednisone \>10mg per day (or other equivalent doses of glucocorticoids) within 7 days before enrollment \[If used for the treatment of diseases other than lymphoma, such as rheumatoid arthritis, polymyalgia rheumatica, adrenal insufficiency, or asthma, subjects may receive a stable dose of up to 10 mg per day of prednisone (or an equivalent dose of other glucocorticoids).\]; 10. Underwent chimeric antigen receptor T cell immunotherapy (CAR-T therapy) within 3 months before enrollment. 7. After the previous treatment (chemotherapy or biological therapy), there are persistent Grade 2 or higher \[Common Terminology Criteria for Adverse Events (CTCAE) V5.0 criteria\] toxicities that have not stabilized at the time of enrollment (alopecia excluded); 8. There is an active clinical severe infection of Grade 2 or higher (CTCAE V5.0 criteria); 9. Co-morbid conditions: 1. Poorly controlled diabetes mellitus \[with a random blood glucose level ≥11.1 mmol/L or Glycosylated Hemoglobin, Type A1C (HbA1c) ≥8.5% despite hypoglycemic treatment\]; 2. Severe pulmonary disease (CTCAE V5.0 Grade III-IV); 3. Severe cardiac disease \[Including any of the following: left ventricular ejection fraction (LVEF) \<50% detected by cardiac radionuclide scan \[Multigated Acquisition (MUGA)\] or echocardiogram (ECHO); Fridericia-corrected QT value (QTcF interval) \>450ms for males and \> 470ms for females (QTcF formula); unstable angina; symptomatic pericarditis; myocardial infarction within the past 6 months with persistent elevation of cardiac enzymes or persistent regional left ventricular wall abnormalities recorded during LVEF measurement; history of congestive heart failure (New York Heart Association Class III-IV), or history of cardiomyopathy.\]. 4. Significant renal or hepatic dysfunction; 5. Uncontrolled active hepatitis B, hepatitis C, syphilis (individuals with both specific and non-specific syphilis antibodies positive), and active Epstein-Barr virus infection \[The following active infections with clinical significance, including hepatitis B (HBV), hepatitis C (HCV), and syphilis. Active hepatitis B is defined as: hepatitis B surface antigen (HBsAg) or hepatitis B e antigen (HBeAg) or hepatitis B core antibody positive, and HBV DNA ≥ 2000 IU/ml (approximately equal to 10\^4 copies/ml), hepatitis B surface antigen (HBsAg) or hepatitis B e antigen (HBeAg) positive, HBV DNA \< 2000 IU/ml, according to the requirements of infectious disease control, the subject should continue to take antiviral drug treatment); active hepatitis C is defined as: HCV RNA above the upper limit of detection; positive syphilis spirochete antibody test, should be tested for non-specific syphilis spirochete antibodies \[Rapid Plasma Reagin Test (PRP) or Toluidine Red Unheated Serum Test (TRUST)\], the latter is negative and the subject is judged by the researcher to have been infected with syphilis in the past but has been cured can be included; current EB virus infection refers to EB virus serological detection of Epstein-Barr Virus Capsid Antigen Immunoglobulin M (VCA-IgM), Epstein-Barr Virus Early Antigen Immunoglobulin G (EA-IgG) positive or EB virus DNA test positive.\]; 6. Known positive for human immunodeficiency virus (HIV); 7. History of mental illness, family history of mental illness, or mood disorders as judged by the investigator or psychiatrist \[Including a medical history of depressive episodes, bipolar disorder (Type I or II), obsessive-compulsive disorder, schizophrenia, suicide attempts or suicidal ideation, or thoughts of killing (immediate risk of harming others), and anxiety levels above Grade 3.\], and deemed unsuitable for enrollment by the investigator; 8. Need for concomitant anticoagulant or antiplatelet therapy during the study period; 9. Uncontrolled hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg); 10. Severe internal medical conditions with a risk of major bleeding or a history of major bleeding. 10. Concurrent use of drugs that may cause QT interval prolongation or torsades de pointes; 11. Within 4 weeks prior to enrollment, currently receiving or requiring treatment with strong inhibitors or inducers of cytochrome P450 (CYP) 3A4 isoenzyme after enrollment (Within 4 weeks prior to enrollment and during the study period, subjects must not receive treatment with strong inhibitors or inducers of the cytochrome P450 (CYP) 3A4 isoenzyme. However, concurrent treatment with moderate or weak CYP3A4 inhibitors is permitted.); 12. Within 4 weeks prior to enrollment, participated in other clinical trials and used investigational drugs; 13. Any unstable condition or situation that may jeopardize the subject's safety and compliance with the study as judged by the investigator; 14. Subjects deemed unsuitable for treatment with this protocol by the investigator.