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New mouthwash formula aims to fight plaque on dental implants

NCT ID NCT06770114

Disease control Sponsor: Colgate Palmolive Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new mouthwash containing CPC, hyaluronic acid, and zinc lactate against a standard fluoride mouthwash. The goal was to see if it reduces plaque and prevents gum problems in adults with at least two dental implants. Eighty participants used the mouthwash for six months, and researchers measured gum inflammation and plaque levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mouthwash containing cetylpyridinium chloride, hyaluronic acid, and zinc lactate
What this could lead to
If it works, this could offer a new option for people with dental implants to better control plaque and gum inflammation.
What could go wrong
This is a small, completed Phase 3 trial with only 80 participants, so results may not apply to everyone. The improvement over standard fluoride mouthwash may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

80 people

The number who actually took part.

Started

Oct 2021

Finished

May 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Availability for the six-month duration of the clinical research study. * Good general health. * Minimum of two dental implants (2 different quadrants ), each implant must have a restoration. * Initial mucositis index of at least 1 .0 as determined by the use of the Mombelli Modified Gingival Index. * Initial plaque index of at least 1 .5 as determined by the use of the Mombelli Modified Plaque Index. * Signed Informed Consent Form. Exclusion Criteria: * Presence of orthodontic bands. * Tumor (s ) of the soft or hard tissues of the oral cavity. * Advanced periodontal disease (purulent exudate, tooth mobility, and /or extensive loss of periodontal attachment or alveolar bone ) or peri-implantitis. * Five or more carious lesions requiring immediate restorative treatment. * Antibiotic use any time during the one-month period prior to entry into the study. * Participation in any other clinical study or test panel within the one month prior to entry into the study. * Dental prophylaxis during the past two weeks prior to baseline examinations. * History of allergies to oral care /personal care consumer products or their ingredients. * On any prescription medicines that might interfere with the study outcome. * An existing medical condition that prohibits eating or drinking for periods up to 4 hours. * History of alcohol or drug abuse. * Self-reported pregnant or lactating subjects

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Conditions

The condition(s) this trial relates to.

gingivitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis

Contacts and locations

Locations

  • Clinica Odontoiatrica Montesani

    Roma, Rome, 00187, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.