New scan could reveal hidden uterine injury after cancer radiation
NCT ID NCT06518174
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether a new imaging technique called shear-wave elastography (SWE) combined with MRI can detect radiation-induced injury to the uterus. Researchers recruited women who had pelvic radiation before age 40 and compared their scans to healthy controls. The goal was to see if these scans could reliably measure uterine fibrosis and other damage.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MRI, SWE, and US evaluation
- What this could lead to
- If successful, this imaging approach could help doctors identify uterine damage from radiation, potentially guiding future fertility-preserving treatments.
- What could go wrong
- This is a very small, early pilot study (only 8 participants) that was terminated, so results may be limited and not generalizable. The imaging techniques are still experimental for this use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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8 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Female 2. Less than 40 years old "at the time of pelvic radiation" 3. ≥ 18 and \< 45 years of age "at time of enrollment" 4. Treated with PRT at UCH 5. Pelvic MRI taken before the pelvic radiation Exclusion Criteria: 1. Patients who underwent hysterectomy for treatment of a primary gynecologic malignancy 2. Patients that are currently pregnant
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Colorado
Aurora, Colorado, 80045, United States