Electric brain stimulation shows promise for aphasia after stroke
NCT ID NCT05194566
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a gentle electrical current applied to the brain (tACS) during language therapy can help people with post-stroke aphasia name objects more accurately. 64 adults with aphasia will receive either real or sham stimulation while practicing word-naming tasks. The goal is to see if the combination boosts recovery of speech.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial alternating current stimulation (tACS) device
- What this could lead to
- If it works, this could offer a new therapy to help stroke survivors with aphasia regain the ability to name objects and speak more easily.
- What could go wrong
- This is an early-stage trial with only 64 participants, so results may not apply to everyone. The improvement may be small or limited to trained words.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 64 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2023
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Individuals with aphasia (assessed using the Boston Diagnostic Aphasia Examination) who perform the Naming Task in the range of 10%-60% accuracy will be included in the study. The overall baseline score in the Naming Task will be estimated from the two baseline measurements. Inclusion Criteria: * diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist). * presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination); * chronic stage of the disease - time since the stroke occurred over 6 months. * ability to achieve an accuracy in the Naming Task of 10-60%. * 18-80 years * right-handedness before the stroke. * ability to give informed written consent. * fluency in English. Exclusion Criteria: * severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command. * presence of metal implants in the skull. * presence of major untreated or unstable psychiatric disease. * history of epilepsy or seizures. * ongoing medication that increases the risk of epileptic seizures. * presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted). * history of speech, language, hearing, or intellectual disability during childhood. * pregnancy (based on declarations) Exclusion criteria during the trial: * high intolerance to stimulation. * occurrence of an epileptic seizure. * other previously absent neurological or mental symptoms Withdrawal criteria: * high intolerance to stimulation (participants experience severe discomfort during stimulation); * occurrence of an epileptic seizure; * other previously absent neurological, physical or mental symptoms.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Abilities Research Center at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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Think & Speak Lab at Shirley Ryan AbilityLab
RECRUITINGChicago, Illinois, 60611, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gentle brain zaps may boost speech recovery after stroke
- Acupuncture with electric current may help stroke survivors speak again
- Magnetic pulses aim to restore speech after stroke
- Brain zaps show promise for stroke speech loss
- Could 100 hours of speech therapy transform life after stroke?
- Zap your way back to speech? new brain stimulation trial for stroke survivors